7. Henry JT, Coker O, Chowdhury S, et al. Comprehensive clinical and molecular characterization of KRAS G12C-mutant colorectal cancer. JCO Precis Oncol. 2021;5:613-621. 8. Chida K, Kotani D, Masuishi T, et al. The prognostic i...
KRAS mutation in cancer.aThe frequency of KRAS mutations across tumour types, including the mutation frequency of common sites and the subtype with the highest mutation rate in different tumour types. KRAS mutations are characterised by single-base missense mutations, 98% of which are found at codo...
miR-34c-3p targets CDK1 a synthetic lethality partner of KRAS in non-small cell lung cancer Francesco Palma Alessandra Affinito Cristina Quintavalle ArticleOpen Access18 Sep 2020 Cancer Gene Therapy The proprotein convertase furin is a pro-oncogenic driver in KRAS and BRAF driven colorectal ca...
KRAS gene mutations and gender differences in colorectal cancer. Int. J. Biomed., 5: 11-15. DOI: 10.21103/Article5(1)_CR2Vodolazhskiy DI, Gevorkyan YA, Soldatkina NV, et al. KRAS gene mutations and gender differences in colorectal cancer[J]. International Journal of BioMedicine, 2015, 5...
3. Bekaii-Saab TS, Spira AI, Yaeger R, et al. KRYSTAL-1: updated activity and safety of adagrasib (MRTX849) in patients (Pts) with unresectable or metastatic pancreatic cancer (PDAC) and other gastrointestinal (GI) tumors harboring ...
14. Ye Zu-Lu, Qiu Miao-Zhen, Tang Tao, et al. Gene mutation profiling in Chinese colorectal cancer patients and its association with clinicopathological characteristics and prognosis.[J] .Cancer Med, 2020, 9: 745-756. 15. Henry Jason T, Coker Oluwadara, Chowdhury Saikat, et al. Comprehens...
7. Henry JT, Coker O, Chowdhury S, et al. Comprehensive clinical and molecular characterization of KRAS G12C-mutant colorectal cancer. JCO Precis Oncol. 2021;5:613-621. 8. Chida K, Kotani D, Masuishi T, et al. The prognostic impact of KRAS G12C mutation in patients with metastatic ...
Engl J Med (2021)[2] Nassar AH, Adib E, Kwiatkowski DJ. Distribution of KRAS G12C somatic mutations across race, sex, and cancer type. N Engl J Med 2021 [3] New research uncovers how cancers with common gene mutation develop resistance to targeted drugs（来源：Dana-Farber 癌症研究所）
[2] Nassar AH, Adib E, Kwiatkowski DJ. Distribution of KRAS G12C somatic mutations across race, sex, and cancer type. N Engl J Med 2021 [3] New research uncovers how cancers with common gene mutation develop resistance to targeted drugs(来源:Dana-Farber 癌症研究所)...
The importance of thedetection of the K-ras gene to return to the top up The K-ras gene can be anormal state (called a wild type) or an abnormal state (mutation). K-ras mutantencodes an abnormal protein that stimulates growth and spread of cancer cellsand is not affected by upstream ...