However, its role as a prognostic marker of overall survival independent of anti-EGFR therapy remains less clear.2 This is especially true for rectal cancer where studies have shown conflicting results on the predictive value of KRAS mutation status on response to neoadjuvant chemoradiation therapy. ...
Conclusion Themutationrateofcodon12inthecoloncancergeneishigh ; KRASmutationsoccurfrequentlyinfemale , righthemicoloncancerandhighserumCEAlevelpatients.MoremutationsintheKRASgenesuggestapoorclinicalprognosisandcanguidefortreatment. Keywords : colonicneoplasms ; KRASgene ; genemutation 随着人民生活水平的提高和现代...
et al. Whole genome analysis for liver metastasis gene signatures in colorectal cancer. Int. J. Cancer 121, 2005–2012 (2007). Google Scholar Kaiser, S. et al. Transcriptional recapitulation and subversion of embryonic colon development by mouse colon tumor models and human colon cancer. ...
For example, in the last few years, we've observed that mutations in KRAS predict resistance to anti-EGFR therapeutics in colon cancer. Earlier this year, the US Food and Drug Administration approved the first ever KRAS inhibitor for use in patients, in this case non-small cell lung cancer...
KRAS、BRAF基因突变的结直肠癌患者临床病理特征分析 ㊃论著㊃ ＫＲＡＳ㊁ＢＲＡＦ基因突变的结直肠癌患者临床 病理特征分析 刘威１，王菲２，杜洪３，缪娜波３，李旺林１，２，曹杰１，２∗ （１．广州医科大学附属广州市第一人民医院，广州消化疾病中心，结直肠肛门外科，广东广州５１０１８０；２．广州市第...
TheRASgene family is among the most studied and best characterized of the known cancer-related genes. Of the three human ras isoforms,KRASis the most frequently altered gene, with mutations occurring in 17%–25% of all cancers. In particular, approximately 30%–40% of colon cancers harbor a...
The phosphoinositide 3-kinase (PI3K)–Akt axis is one of the most frequently activated pathways and is demonstrated as a therapeutic target in Kirsten rat sarcoma viral oncogene homolog (KRAS)-mutated colorectal cancer (CRC). Targeting the PI3K–Akt pathway has been a challenging undertaking through...
Erbitux (Erbitux, cetuximab and panitumumab) (Panitumumab) applies only to thewild type K-RAS gene in patients with no mutations, mutation of K-RAS patientsis invalid. The national comprehensive cancer network (NCCN) classified theK-RAS test as a guideline for clinical treatment of colon cancer...
GATA3, as another hub gene in the present study, is expressed in CRC with a suppressive effect on the invasive behavior of CRC cells41. Methylation of cyclin dependent kinase inhibitor 2A (CDKN2A) promoter and subsequent gene silencing have been documented in many tumors including colon cancer ...
STRUCTUREANDFUNCTIONOFKRASGENEANDCRISPR/CAS9RELATEDTECHNOLOGIES Abstract Krasgenemutation,oneofthedrivinggenesofcoloncancer,hasalwaysbeenoneofthehottopicsinacademia.Krasisthemostcommonmutationinhumancancers(suchaspancreaticcancer,colorectalcancerandlungcancer),accountingforabout30%ofthetotalmutationrate,andevenashighas...