Gene mutationNon–small cell lung cancerA new somatic mutation in the coding region of Kirsten rat sarcoma viral oncogene homolog gene (KRAS), G48A, has been identified in a patient with non鈥搒mall cell lung cancer (NSCLC). No other mutations were found by screening several genes known to...
Haratani K, Hayashi H, Tanaka T, et al. Tumor immune microenvironment and nivolumab efficacy in EGFR mutation-positive non-small-cell lung cancer based on T790M status after disease progression during EGFR-TKI treatment. ...
The relationship between common EGFR, BRAF, KRAS mutations and prognosis in advanced stage non-small cell lung cancer with response to the treatment in ... Dogan,Mutlu - UHOD - Uluslararasi Hematoloji-Onkoloji Dergisi 被引量: 7发表: 2014年 EGFR and KRAS Gene Mutations in 754 Patients with...
【关键词】 非小细胞肺癌; KRAS 基因; 临床病理特征基金项目:山东省潍坊市卫生健康委科研项目(WFWSJK -2020-049,WFWSJK -2020-078)Analysis of KRAS gene mutation and clinicopathological characteristics in patients with non -small cell lung cancer Zhao Shouxiang, Guo Qin, Li Ying, Wang Tao, Tian Sh...
Haratani K, Hayashi H, Tanaka T, et al. Tumor immune microenvironment and nivolumab efficacy in EGFR mutation-positive non-small-cell lung cancer based on T790M status after disease progression during EGFR-TKI treatment. Ann Oncol, 2017, 28(7): 1532-1539. doi: 10.1093/annonc/mdx183 ...
图片来源:Cancer Gene Ther. doi: 10.1038/s41417-023-00717-9. 研究显示,针对KRAS突变的粘膜肽疫苗具有诱导针对KRAS突变型肺癌的强烈局部免疫反应的潜力,为NSCLC的预防和治疗提供了一条有前景的途径。 总的来说,该研究通过开发一种针对KRAS突变的...
providing renewed hope for patients that harbor a KRAS G12C mutation. It is compelling for a 45% confirmed objective response rate for adagrasib (1) as a monotherapy in advanced NSCLC. The news electrifying the drug industry and everyone, including the cancer patients, doctors, researchers, an...
this gene was identified as a human homologue of the RAS gene, named HRAS, located on the short arm of chromosome 11 (11p15.1–11p15.3)12. In the same year, another homologue was found in human lung cancer cells, called KRAS, located on the short arm of chromosome 12 (12p11.1–12p12.1...
非小细胞肺癌EGFR和KRAS基因突变和临床病理特征分析 ［９］ 于亚波，丛占杰．老年非小细胞肺癌ＥＣＯＧ评分、ＣＹＦＲＡ２１－１、ＮＳＥ与外科手术预后关系［Ｊ］．临床与实验病理学杂志，２０１７，３３（７）：８０６－８０９．［１０］靳宏虎，赵长应，张桢，等．两种实体瘤疗效评价标准对肝细胞癌 患者系统...
Brief Communication10 Jul 2020 Cancer Gene Therapy HSP90/AXL/eIF4E-regulated unfolded protein response as an acquired vulnerability in drug-resistant KRAS-mutant lung cancer Haitang Yang Shun-Qing Liang Ren-Wang Peng ArticleOpen Access20 Aug 2019 Oncogenesis Initiation of human mammary cell tumo...