因此,迫切需要开发针对KRAS突变CRC的其他改进疗法。 近日,来自美国哈佛医学院Brigham and Women’s Hospital的Karen Cichowski教授在Cancer Discovery杂志上发表文章Epigenetic and oncogenic inhibitors cooperatively drive differentiation and kill ...
KRAS突变型癌症的多组学综合表征 今天和大家分享一篇于2022年8月在Theranostics上发表的文章"Integrated multi-omics characterization of KRAS mutant colorectal cancer"。KRAS突变是结直肠癌(CRC)中最常见的致癌异常。CRC中KRAS突变的分子机制和临床意义尚不清楚,并在这些肿瘤...
Immune landscape and prognostic immune-related genes in KRAS-mutant colorectal cancer patients 发生KRAS突变结直肠癌患者的免疫情况概况 一、研究背景 KRAS突变是结直肠癌最常见的突变类型。KRAS突变能够作为EGFR-TKI耐药性的生物标记物并在鉴定抗表皮生长因子受体(EGFR)治疗,这些研究证据表明,KRAS突变对肿瘤免疫力有...
2023年6月，《Nature Communications》杂志发表了一篇题为《Targeting of SLC25A22 boosts the immunotherapeutic response in KRAS-mutant colorectal cancer》的研究，揭示了KRAS突变型CRC免疫抑制微环境形成的新机制，并提出了一个全新的视角和潜在的治疗策略：通过靶向SLC25A22，可以增强KRAS突变型CRC对免疫疗法的反应，...
近日,来自美国哈佛医学院Brigham and Women’s Hospital的Karen Cichowski教授在Cancer Discovery杂志上发表文章Epigenetic and oncogenic inhibitors cooperatively drive differentiation and kill KRAS-mutant colorectal cancers。本研究描述了一种有前景的治疗策略,该策略同时针对表观遗传和致癌信号。具体而言,研究表明组蛋白甲...
1. National Cancer Institute. Cancer Stat Facts: Colorectal Cancer 2022. Accessed December 8, 2022. 2. Dienstmann R, Connor K, Byrne AT; COLOSSUS Consortium. Precision therapy in RAS mutant colorectal cancer. Gastroenterology. 2020;158(4):806-811. ...
今天,小编就来带大家看一篇2022年7月发布于Nature子刊的一篇名为The cholesterol uptake regulator PCSK9 promotes and is a therapeutic target in APC/KRAS-mutant colorectal cancer(IF:11.8780)的APC/KRAS结直肠癌新治疗靶点机制研究前沿文章。 团队研究确定PCSK9是调节胆固醇稳态的关键基因,PCSK9过表达可诱导癌变减...
KRAS mutation in lung metastases from colorectal cancer: prognostic implicationsdoi:10.1002/cam4.592BRAFbrain metastasescancercolorectalKRASlung metastasesKRAS mutant colorectal cancer (CRC) patients develop lung and brain metastases more frequently than KRAS wild-type (WT) counterpart. We retrospectively ...
题目：Immune landscape and prognostic immune-related genes in KRAS-mutant colorectal cancer patients 发生KRAS突变结直肠癌患者的免疫情况和预后免疫相关基因 摘要 背景：KRAS突变是结直肠癌最常见的突变类型。KRAS突变介导的CRC免疫表型和免疫通路调控尚待阐明。方法：比较KRAS突变型和野生型患者肿瘤微环境中免疫相关...
1. National Cancer Institute. Cancer Stat Facts: Colorectal Cancer 2022. Accessed December 8, 2022. 2. Dienstmann R, Connor K, Byrne AT; COLOSSUS Consortium. Precision therapy in RAS mutant colorectal cancer. Gastroenterology. 2020;158(4)...