1. The “What” of APOE transgenic AD mouse models: the development of AD pathology and the effect of universal biological variables Alzheimer’s Disease (AD) is a complex, uniquely human condition that has eluded understanding and effective treatment for over a century. Nevertheless, dozens of ...
We also review the use of magnetic resonance imaging findings as an outcome measure in clinical trials assessing the efficacy of new therapeutic agents for the treatment of multiple sclerosis. More advanced applications of magnetic resonance imaging and their use in multiple sclerosis is addressed ...
and when these are not balanced they boost the response in the Central Nervous System and immune systems. As stated in the study, “CBD is an interesting compound because of its ability to control reactive gliosis in the CNS, without any unwanted psychotropic effects.” ...
Autoimmune encephalitis is a relatively novel nosological entity characterized by an immune-mediated damage of the central nervous system. While originally described as a paraneoplastic inflammatory phenomenon affecting limbic structures, numerous instances of non-paraneoplastic pathogenesis, as well as extra-...
involves the interaction of several molecular pathways that impact cellular functions. These pathways ultimately result in the destruction of neural connections, cellular death, gliosis and inflammation, which in turn causes a person to lose cognitive functioning—the ability to think, remember, and ...
involves the interaction of several molecular pathways that impact cellular functions. These pathways ultimately result in the destruction of neural connections, cellular death, gliosis and inflammation, which in turn causes a person to lose cognitive functioning—the ability to think, remember, and ...
2. Curcumin and Neurological Disease: Focusing on Mechanism The possibility of using curcumin as a treatment for neurological diseases is a relatively recent development. Although the specific effects may differ for each disease, we can identify common pathways by which curcumin exerts its effects. Fo...
Neuroinflammation is also involved in the complex cascade leading to AD pathology and symptoms. It has been shown that AD is associated with increased levels of cycloxygenase 1 and 2 and of prostaglandins, release of cytokines and chemokines, acute phase reaction, astrocytosis and microgliosis [...