Mild brain injury aggravates gliosis, toxic tau, and anxiety in the P301S model of TAUopathydoi:10.1002/alz.072502Marco, Ana RoyoAlzheimer's & Dementia: The Journal of the Alzheimer's Association
Prolonged mild hypothermia therapy protects the brain against permanent focal ischemia. BACKGROUND AND PURPOSE: The efficacy of hypothermic intervention for permanent focal ischemia has yet to be clarified. This study investigated the effect o... H Yanamoto,I Nagata,Y Niitsu,... - 《Stroke A ...
Mild traumatic brain injury DTI fMRI Meta-analysis Neuropsychological assessments Post concussion syndrome 1. Introduction Two important points about today's neuroimaging clinical standard of care of mTBI may be surprising. First, even though MRI is a premier modality for imaging the brain, when used...
In addition, at 7dpi, we measured 39 changes in Iba1 and GFAP to determine the extent of gliosis. The expression of disease- 40 associated protein markers in grey and white matter regions were evaluated using the 41 NanoString-GeoMx digital spatial protein profiling (DSP) platform. The rs...
uncertainty of orientation distribution function WT Wildtype 1. Introduction The term traumatic brain injury (TBI) is broadly used to describe an injury to the head or body caused by an external force or penetrating injury that disrupts normal brain function (Moore and Sandsmark, 2023; Pavlovic et...
Pathological features have included large- and small-vessel disease, gliosis, microvascular brain damage (severe cribri- form change), white matter damage, microinfarction and haemorrhage [104]. Cardiovascular risk factors have also been associated with AD-like neuropathological lesion formation in ...
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(that is, irreversible loss of brain tissue) and VE are characteristic features of AD46,47, and neuroinflammation is a known phenomenon in AD48. Although ‘pseudoatrophy’ (that is, VE due to resolution of inflammatory edema and gliosis) has been described in clinical studies of multiple ...
Tau aggregates also may be packaged inside exosomes, some of which enter CSF or may even transit from the brain into blood. Although the neuro-pathogenic potential of NDEs has yet to be investigated, their role as biomarkers is being clarified. Synapse loss and dysfunction is another pathologic...
gliosis, and progressive neuronal loss are initiated and continue to progress into the clinical state of overt dementia9. Accumulating evidence supports that various clearance mechanisms of toxic aggregation of misfolded peptides from the brain to the blood account for a determinate amount of Aβ ...