Gliosis in the BrainEncephalic radiation therapy delivered at a conventional dose rate (CONV, 0.1-2.0 Gy/min) elicits a variety of temporally distinct damage signatures that invariably involve persistent indications of neuroinflammation. Past work has shown an involvement of both the innate and ...
Define gliosis. gliosis synonyms, gliosis pronunciation, gliosis translation, English dictionary definition of gliosis. n med a process leading to scarring in the central nervous system Collins English Dictionary – Complete and Unabridged, 12th Edition
There were some studies showing that a certain number of BMDSCs marked with Y chromosome and GFP gene and grafted through the vein of the host animals could be presented in their brain tissue and these migrated cells expressed the specific markers for glial and neuronal cells. 骨髓源干细胞(...
Here we have studied the effects of a humanized APOEε4 liver[6] on synaptic integrity, insulin signaling and gliosis in a mouse model that reproduces the human plasma profile and that retains its endogenous apoE expression in the brain. Tissue samples from the cortex, hippocampus, cerebellum...
The contribution of gliosis to diffusion tensor anisotropy and tractography following traumatic brain injury: validation in the rat using Fourier analysis ... Diffusion tensor imaging is highly sensitive to the microstructural integrity of the brain and has uncovered significant abnormalities following trau...
1i). These results provide strong evidence that APOE gene expression is selectively eliminated in neurons when Cre recombinase expression is driven under a Syn1 promoter, while leaving APOE expression in other relevant APOE-expressing cell types in the brain, which is confirmed by single-nucleus ...
However, the molecular basis of its therapeutic effect remains unclear. Considering the growing evidence for the importance of glial cells for neuronal development, survival and plasticity, we investigated astrocyte protein markers from KD fed rats, in different regions of hippocampus, a brain structure...
Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by glia over-proliferation, neuro-inflammation, perturbed neural circuitry, and gastrointestinal symptoms. The role of gut dys-biosis in ASD is intriguing and should be elucida
1a). Similarly, Mac-2 was also colocalized with microglia/macrophages and astrocytes in the hemorrhagic mouse brain (Fig. 1g). By quantifying the number of Mac-2+/Iba-1+ microglia/macrophages and Mac-2+/GFAP+ astrocytes in the gliosis region at 14 days after MCAO, we found that 25...
Gliosis was also shown in human post mortem brain biopsy [24,25,26]. Although, gliosis is a certainly proved pathological feature of NPC1 the role of glial cells in the progression of the disease is controversially discussed. Recently we developed a human cell model system, based on ...