Autoimmune encephalitis is a relatively novel nosological entity characterized by an immune-mediated damage of the central nervous system. While originally
TXNIP Links Innate Host Defense Mechanisms to Oxidative Stress and Inflammation in Retinal Muller Glia under Chronic Hyperglycemia: Implications for Diabet... Thioredoxin Interacting Protein (TXNIP) mediates retinal inflammation, gliosis, and apoptosis in experimental diabetes. Here, we investigate the ...
GLIOSISCENTRAL nervous system diseasesCENTRAL nervous systemBLOOD-brain barrierMultiple sclerosis is an autoimmune inflammatory disease of the central nervous system leading to neurodegeneration. It affects 2.3 million people worldwide, generally younger than 50. There is no known c...
Koopmans RALi DKBOger JJFMayo JPaty DW The lesion of multiple sclerosis: imaging of acute and chronic stages. Neurology. 1989;39959- 963Google ScholarCrossref 51. Paty DWLi DKBUBC MS/MRI Study Group, IFNB Multiple Sclerosis Study Group, Interferon beta-1b is effective in relapsing-remittin...
An effective resolution program may be able to prevent the progression from non-resolving acute inflammation to persistent chronic inflammation. It has now... MA Sugimoto,LP Sousa,P Vanessa,... - 《Frontiers in Immunology》 被引量: 77发表: 2016年 Hypothalamic inflammation and gliosis in obesity...
(MS) is a chronic, persistent inflammatory demyelinating disease of the central nervous system (CNS), characterised pathologically by areas of inflammation, demyelination, axonal loss, and gliosis scattered throughout the CNS, mainly affecting the optic nerves, brainstem, spinal cord, and cerebellar ...
What: AD is uniquely human, but molecular mechanisms can be measured in Tg mice. • Who: A universal biological variable of AD, APOE is critical for preclinical models. • How: There are several strategies for developing APOE-Tg mice. • When/Where: Developmental and region-specific mode...
“Leukoaraiosis (LA) is a disease manifested by demyelination and gliosis in white matter, mainly caused by cerebrovascular diseases,” Yan Wang and colleagues wrote. “Leukoaraiosis is closely related to the expression level of inflammatory factors, oxidative stress, and vascular endothelial dysfu...
The human immunodeficiency virus type 1 (HIV-1) trans-activator of transcription protein Tat is an important factor in viral pathogenesis. In addition to its function as the key trans-activator of viral transcription, Tat is also secreted by the infected cell and taken up by neighboring cells ...
Koopmans RALi DKBOger JJFMayo JPaty DW The lesion of multiple sclerosis: imaging of acute and chronic stages. Neurology. 1989;39959- 963Google ScholarCrossref 51. Paty DWLi DKBUBC MS/MRI Study Group, IFNB Multiple Sclerosis Study Group, Interferon beta-1b is effective in relapsing-remittin...