Diffuse brainstem glioma is a rare disease in adults. Radiotherapy (RT) is usually considered to be the standard treatment. However, the role of chemotherapy in treating relapses after RT is unclear, and this study aimed to assess the use of temozolomide (TMZ) in this situation. We conducted...
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Based on these results, an international, randomized, placebo-controlled phase III trial is underway in patients with newly diagnosed H3 K27M-mutant diffuse gliomas (excluding pontine and spinal tumors) [31]. (See "Diffuse intrinsic pontine glioma", section on 'Investigational therapies'.) ...
Secondly, there are molecular reasons why the COVID-19 virus may impact on cardiovascular health in patients. So, it's been shown that the angiotensin II receptor found both in the heart but also in lung tissue and alveolar cells, is a receptor for the COVID-19 virus. And there have be...
period that the hematoma is not yet organized; in this case, the goal is the complete removal, preventing recurrence of bleeding and functional worsening.1,14,15However, before indicating the surgical procedure, the main differential diagnosis (pontine glioma and multiple sclerosis) must be excluded...
tumours such as craniopharyngioma, glioma, pituitary adenoma and germ cell tumours compressive cysts can also form in the sellar/suprasellar region in childhood, including arachnoid and Rathke Cleft Cysts. Any of these compressive lesions can result in a bi-temporal hemianopia if the chiasm is ...
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The new challenge is suggested( 提议) by an organization called Aubreigh's Army ,with the (88)p___of supporting the fight against Diffuse Intrinsic Pontine Glioma(神经胶质瘤). Eleven-year-old Aubreigh Nicholas was diagnosed(诊断)with DIPG and the organization hopes to raise $ 50 ,000 for...
In addition, another pathway to recruit T cells to the glioma TME is the lymphatic system, with functional lymphatic vessels lining the dural sinus and connecting to the deep cervical lymph nodes [7]. This system is part of the recently discovered glymphatic system, which is considered an ...
MELAS with diffuse degeneration of the cerebral white matter: Report of an autopsy case. Neuropathology 2010, 30, 56–60. [Google Scholar] [CrossRef] Hoban, M.D.; Orkin, S.H.; Bauer, D.E. Genetic treatment of a molecular disorder: Gene therapy approaches to sickle cell disease. Blood ...