Diffuse midline glioma, H3 K27M-mutant, formerly known as diffuse intrinsic pontine glioma (DIPG), is a malignant and infiltrative neoplasm of the pons. DIPG mainly affects the pediatric population and is associated with dismal prognosis, where less than 10% of sufferers survive beyond 2 years...
Also known as: Diffuse Midline Glioma / Midline Diffuse Glioma Drug Trials Show entries DrugDrug NamePhaseStatusCount DB00988 Dopamine 1 Recruiting 1 DB12091 Gadolinium 1 Completed 1 DB11066 Pancrelipase protease 1 Recruiting 1 DB14844 Dordaviprone 2 Active Not Recruiting 1 DB00997 Doxorubicin ...
Diffuse midline gliomas (DMGs) are malignant pediatric brain tumors characterized by H3K27M mutation and global genome hypomethylation. This results in enhanced transcription of MGMT, a DNA-repair enzyme, rendering alkylating chemotherapeutics ineffective. Therefore, we investigated the efficacy of a ...
Diffuse midline glioma (DMG) is a devastating high-grade glioma (HGG) responsible for 50% of all childhood HGGs [1]. DMG is most frequently diagnosed in the brainstem (especially the pons, where it has historically been called diffuse intrinsic pontine glioma - DIPG), and less frequently in...
Children diagnosed with diffuse midline gliomas often die within a year after their initial diagnosis since there are no effective treatments yet for this rare cancer. But researchers now have a better understanding of what these tumors look like and can work towards developing new treatment approache...
(IDH)-mutant glioma33,35,36,37. To investigate whether this may be a phenomenon specific to the midline location, we single-cell profiled two location- and age-matched IDH-mutant midline gliomas (Supplementary Table1), revealing that neuronal lineage programs are present within rare midline IDH...
Diffuse gliomas represent the most frequent primary brain tumours in adults. In the last years, landmark studies led to tremendous advances in terms of the knowledge of the molecular bases of gliomagenesis. This resulted in a paradigm shift in their classification. Regrettably, such advances have ...
cells Review H3K27me3 in Diffuse Midline Glioma and Epithelial Ovarian Cancer: Opposing Epigenetic Changes Leading to the Same Poor Outcomes Charles A. Day 1,2,* , Edward H. Hinchcliffe 1,3 and James P. Robinson 1,3 1 Hormel Institute, University of Minnesota, Austin, MN 55912, USA 2 ...
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A four-year-old female presented with a large solid-cystic lesion centred on the suprasellar cistern, histologically revealed to be diffuse midline glioma H3 K27M-mutant. The patient received multiple courses of radiotherapy to the primary lesion and metachronous spinal metastases, and underwent ...