P10.11.A CHARACTERISTICS OF DIFFUSE MIDLINE GLIOMA WITH H3 K27M MUTATION IN ADULTSdoi:10.1093/neuonc/noad137.209BACKGROUND. H3 K27M-mutant diffuse midline gliomas (DMG) occur primarily in children but can also be encountered in adults. Adult H3 K27M-mutant DMG is a still challenging disease...
Diffuse midline gliomas (DMGs) are malignant pediatric brain tumors characterized by H3K27M mutation and global genome hypomethylation. This results in enhanced transcription of MGMT, a DNA-repair enzyme, rendering alkylating chemotherapeutics ineffective. Therefore, we investigated the efficacy of a ...
Diffuse midline gliomas (DMG) driven by a lysine27-to-methionine (K27M) mutation in histone 3 (H3) are among the most lethal brain tumors1,2,3,4,5. Primarily identified in younger children (<10 years), the same oncohistone mutation is also recurrently observed in midline gliomas in adul...
Also known as: Diffuse Midline Glioma / Midline Diffuse Glioma Drug Trials Show entries DrugDrug NamePhaseStatusCount DB00988 Dopamine 1 Recruiting 1 DB12091 Gadolinium 1 Completed 1 DB11066 Pancrelipase protease 1 Recruiting 1 DB14844 Dordaviprone 2 Active Not Recruiting 1 DB00997 Doxorubicin ...
Diffuse midline glioma (DMG) is a deadly pediatric and adolescent central nervous system (CNS) tumor localized along the midline structures of the brain atop the spinal cord. With a median overall survival (OS) of just 9–11-months, DMG is characterized
More information:Ilon Liu et al, The landscape of tumor cell states and spatial organization in H3-K27M mutant diffuse midline glioma across age and location,Nature Genetics(2022).DOI: 10.1038/s41588-022-01236-3
This study aims to elucidate the clinical and molecular characteristics, treatment outcomes and prognostic factors of patients with histone H3 K27-mutant diffuse midline glioma. We retrospectively analyzed 93 patients with diffuse midline glioma (47 thal
midline locations3, and unique recurrent K27M missense mutations in genes encoding the histone H3 characterise approximately 84% of diffuse intrinsic pontine gliomas and 60% of other midline tumours2. Thus, they were defined as a new entity, calleddiffuse midline glioma, H3K27M-mutant(H3K27M ...
Diffuse intrinsic pontine glioma (DIPG) is a highly aggressive pediatric brainstem tumor characterized by rapid and uniform patient demise1. A heterozygous point mutation of histone H3 occurs in more than 80% of these tumors and results in a lysine-to-methionine substitution (H3K27M)2,3. Expres...
As the name "Diffuse Midline Glioma" suggests, these tumors are highly diffuse and intercalated within the surrounding brain tissue. A few case reports have noted metastatic diffuse midline gliomas [107–109], but this occurrence is extremely rare. The highly diffuse nature and the location of ...