Following stimulation in vivo , references 69 and 70 show that most NKT cells do not die within hours due to activation-induced cell death (as previously thought). Instead, they downregulate NK1.1 expression and undergo marked but transient clonal expansion to ten times their steady-state levels...
MRI in the diagnosis of MS: a prospective study with comparison of clinical evaluation, evoked potentials, oligoclonal banding, and CT. Neurology. 1988;38180- 185Google ScholarCrossref 59. Fazekas FOffenbacher HFuchs S et al. Criteria for an increased specificity of MRI interpretation in ...
ResponseProduction and Clonal Expansion in a Th1 g Induction in Postdifferentiation IFN-B k T Cell-Intrinsic Requirement for NF-Mark NF- (cid:1) B/Rel transcription factors are linked to innate immune responses and APC activation. Whether and how the induction of NF- (cid:1) B signaling ....
The extent of clonal expansion and effector cytokine production by T cells is largely proportional to antigen dose and strength. This is, in short, referred as a scaled response. A scaled T cell response is an important functional feature of the immune system. Temporal integration of TCR ...
Defining the mode of tumour growth by clonal analysis. Nature 488, 527–530 (2012). Article CAS PubMed PubMed Central Google Scholar Barker, N. et al. Identification of stem cells in small intestine and colon by marker gene Lgr5. Nature 449, 1003–1007 (2007). Article CAS PubMed ...
When dendritic cells present antigen molecules to antigen-specific T cells, there is clonal expansion of these lymphocytes and subsequent differentiation into effector cells, some of which will, later, establish T-cell memory. In elderly individuals this process is compromised. Li and colleagues [34...
Inhibition of inflammation can impede clonal expansion in response to inflammatory stimuli [102]. Blocking inflammation may also be a valuable therapeutic approach in CVD, as inhibiting IL-1 receptor signaling from pro-inflammatory macrophages can prevent CHIP-associated CVD in mice [68]. It is ...
MRI in the diagnosis of MS: a prospective study with comparison of clinical evaluation, evoked potentials, oligoclonal banding, and CT. Neurology. 1988;38180- 185Google ScholarCrossref 59. Fazekas FOffenbacher HFuchs S et al. Criteria for an increased specificity of MRI interpretation in ...
Martin J. Blaser is at the Department of Medicine and the Department of Microbiology, New York University Langone Medical Center, New York, New York 10017, USA., Martin J. Blaser Stanley Falkow is at the Department of Microbiology and Immunology and the Department of Medicine, Stanford Universit...
their prevalence in human populations is changing, often to an extreme degree. In this Essay, we propose that the disappearance of these ancestral indigenous organisms, which are intimately involved in human physiology, is not entirely beneficial and has consequences that might include post-modern con...