This is still the Achilles heel of current computational drug-discovery efforts, and hence also poses problems when applying AI. We are able to describe chemistry rather well, and have a large amount of proxy assay data available for modelling, hence this type of data has been a key focus ...
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The information gleaned from assays can impact financial markets in various ways. A mining company whose latest assay indicates large quantities of high-grade ore may see its stock price escalate. Medical assays showing the likely development of a new drug therapy or vaccine can be equally positiv...
In effect, FP-based assays have an internal quality control parameter defined as the ratio of the emission intensities of the bound and free probes. Because FP-based assays are frequently utilized in the drug discovery industry, an 'Assay guidance manual' has been published and updated since ...
What is Companion Diagnostics? A Companion Diagnostic (CDx) assay, according to the The United States Food and Drug Administration guidance, is a medical device, often an in vitro diagnostic (IVD), which provides information that is essential for the safe and effective use of a corresponding dr...
Alpha-fetoprotein (AFP) is a glycoprotein entwined with the growth and development of HCC. It performs various functions in tumorigenesis—inducing malignant transformation as well as proliferation, migration, apoptosis, and immune escape [11]. Despite common use, it is characterized by poor sensitivit...
The discovery and clinical validation of biomarkers predictive of the response of non-squamous non-small-cell lung carcinomas (NS-NSCLC) to therapeutic strategies continue to provide new data. The evaluation of novel treatments is based on molecular analyses aimed at determining their efficacy. These...
We have worked with Reaction Biology Europe for 3 years onin vivodrug development assays. They have provided their services from routine PK through efficacy and custom BLI studies in tumor models, consistently generating high-quality results that guided our development process. Their expertise, respons...
Chemistry is so deeply ingrained into so many areas of business, government, and environmental management that some background in the subject can be useful (and able to give you a career edge as a team member having special skills) in fields as varied as product development, marketing, managem...
is to supervise the three most influential factors contributing to the development and transmission of MDROs, namely: (1) appropriate antibiotic prescribing; (2) early detection and prevention of cross-colonization of MDROs; and (3) elimination of reservoirs. In the future, it is expected that a...