During the cell cycle, replication and mitosis are the stages at which epigenetic memory is most likely to be erased. Each stage presents a different molecular challenge to memory. During replication, newly assembled chromatin is acetylated and may favour an active PRE but challenge a silent one....
This article gives an introduction to the patch-clamp technique and how it is used to study the physiology of ion channels for neuroscience and other life-science fields.
(2014) used a STING Antibody to analyze expression in primary breast tumors, metastases, and in 4T1 cell lines with bone marrow and HEK293 as positive control and negative control respectively. This study used an attenuated Listeria monocytogenes (LM)–based vaccine, expressing tumor-associated a...
利用CRISPR/Cas9技术构建敲除MEIS2基因的HEK293T人胚肾细胞系 CRISPR/Cas9系统作为一种新型的基因组编辑技术,利用人工设计的向导RNA(singleguide RNA,sg RNA)介导外源表达的Cas9蛋白与基因组靶点特异性结合以实现对基因组DNA的特... 卢利莎,白杨,刘鑫,... - 《中国细胞生物学学报》 被引量: 12发表: 2015年 ...
What ___ she ___ on TV? (watch)有实验结果显示，如果不是食物中的饱和脂肪酸换成不饱和脂肪，会有利于减少冠心病的发生风险。而橄榄油中则含有70%的油酸，油酸是一种不饱和脂肪酸，因此有专家判断橄榄油是减少冠心病风险的最佳食用油。下列选项如果为真，会对专家的判断产生质疑的有（ ）。
Review AlphaFold and what is next: bridging functional, systems and structural biology Kacper Szczepski & Łukasz Jaremko Pages 45-58 | Received 22 Nov 2024, Accepted 16 Jan 2025, Published online: 12 Feb 2025 Cite this article https://doi.org/10.1080/14789450.2025.2456046 CrossMark In...
Deregulation of Ca2+ signaling as a means to overcome the G1 checkpoint of the cell cycle is an oncogenic hallmark.1 Overexpression of plasma membrane Ca2+ channels in cancer cells includes store-operated channels, transient receptor potential channels, second messenger-operated channels, and voltage...
a given cytokine may be produced by more than one type of cell. They act through cell surface receptors and are especially important in the immune system; It is common for different cell types to secrete the same cytokine or for a single cytokine to act on several different cell types (ple...
Note: TransIT[R]-Lenti Transfection Reagent is only recommended for adherent cell transfections (e.g., HEK 293T/17) and is not recommended for lentivirus generation in suspension cell types. For Lentivirus Production: TransIT[R]-Lenti Transfection Reagent, Available from MoBiTec, Germany HaCaT ce...
To review what we have learned about FM during the past decade, I have formulated a series of questions: How has FM been defined? How and when should FM be diagnosed? What is the association between FM and psychiatric illness? Have pathophysiological abnormalities or causes been identified?