In this mini-review, focusing on BRAF-mutated melanoma as prototypical example, we analyze how recent studies that make use of single cell analysis identify the involvement of distinct transcriptional trajectories as the common thread at the basis of drug tolerance. The identification of these ...
When drug taking is repeated beyond prescribed usage, it often leads to a pattern of drug dependence and tolerance. Tolerance is the body's need for larger or more frequent doses of a substance to achieve the same effect. It occurs when the body has learned to tolerate, or become used to...
The ability to digest or metabolize a food, drug, or other substance or compound Glucose tolerance. Respect To avoid violating I respected the speed limit throughout the trip. Tolerance Acceptance of a tissue graft or transplant without immunological rejection. Respect To relate or refer to; conce...
Due to evolving laws regarding substances and drug testing in general, our organization is considering moving from a zero-tolerance drug and alcohol policy to one where employees will have the ability to return-to-duty after certain violations (...
Question: What does it mean if one can 'manually or consciously control' their own metabolism? Metabolism: Metabolism is the physiological mechanism by which the ingested food is digested and converted into energy that the body can use. This conversion process is achieved through ...
You become tolerant to the opioid. Tolerance means you continue to need higher amounts to feel the effects you want. You are not able to stop, or to take less. You start it again when you try to quit. You try to lower the amount or increase time without it, but you are not able...
Quality control testing is done at the various steps of manufacturing to identify the problems and help prevent them in the future. Quality control is a core process in industries that rely on products. For instance, the food and drug manufacturing industries are quite sensitive because the produc...
Bankruptcy: Definition & When To File What Is a Bear Market and How Should You Invest in One? Intro to Behavioral Finance What Are Bond Funds? What Is a Bull Market? What Does Bag Holder Mean? What Is a Buy & Hold Strategy in Investing?
What Does It Mean to Be 'Triggered' Triggers refer to the experience of having an emotional reaction to a disturbing topic (such as violence or the mention of suicide) in the media or a social setting. However, there is a difference between being triggered and being uncomfortable. "Being t...
①药动Pharmacokinetics:what the body does to drug. Refer to the way the body handles drug absorption, distribution ,metabolism, excretion and toxicity. Onse it is determined, rational, dosage , regimens can be instituted.②药效Pharmacodynamics:what the drug does to body.(1drug receptor.2effect ...