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In addition, each of these classes of antihypertensive drugs includes many different individual molecular entities, each with a specific pharmacokinetic, pharmacodynamic, efficacy, tolerance, and safety profile. This remarkable change in the antihypertensive pharmacopeia, and the corresponding change in many...
Previous studies suggested that measurement of 6-MP metabolite levels can be used to predict clinical efficacy and tolerance to azathioprine or 6-MP (Cuffari et al., Gut 39:401-406 (1996a)). However, it was unknown what concentrations of 6-MP metabolites correlated with optimized therapeutic ...
Nearly all drugs of abuse can also produce a phenomenon known as tolerance, in which one must use a larger amount of the drug to produce the same level of intoxication. Commonly abused drugs include the following: Inhalants: This group of substances includes solvents that emit vapors, causing...
The prevalence of intentional self-injury is increasing and understanding the totality of the disease is complex. Proper, swift treatment is the best way to help prevent any dire consequences of cutting. Why Do People Cut Themselves The motives behind cutting are often counterintuitive....
hydrophila infection were only limited to several antibiotics, which contributed for the fast-speed emergence of drug tolerance [9]. Traditional one-for-all dosing guideline of enrofloxacin is not applicable any more. The failure to control bacterial disease in fish with antibiotics was most likely...
hydrophila infection were only limited to several antibiotics, which contributed for the fast-speed emergence of drug tolerance [9]. Traditional one-for-all dosing guideline of enrofloxacin is not applicable any more. The failure to control bacterial disease in fish with antibiotics was most likely...
Precision medicine aims to develop tailored medical interventions on the basis of an individual’s genetic, environmental, and lifestyle elements.7,8,9However, IVDR is a major barrier to the implementation of precision medicine, as it poses a challenge to predict drug efficacy and identify patients...
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The syndrome of neuroleptic-induced parkinsonism is strikingly similar to other forms of this disorder and usually appears after the first or second week of treatment and within the first month. Some degree of tolerance appears to develop to this extrapyramidal side effect, and the neurologicalsigns...