The test or testing facility is the main location where the study is initiated and conducted. It is not unusual for all phases of a study to be conducted at a single test facility; however, it is often the case that different p...
According to Bakker-Woudenberg, a higher maximum drug tolerance was observed in a rat model when ciprofloxacin was delivered in polyethylene glycol-coated liposome compared to free drug [72]. Microspheres are known as small spherical particles of diameter with a range from 1 to 1000 μm. The ...
There is no FDA-approved medication for methamphetamine (METH) use disorder. New therapeutic approaches are needed, especially for people who use METH heavily and are at high risk for overdose. This study used genetically engineered rats to evaluate PARK
Nevertheless, it seems clear that antibiotic tolerance promoted by biofilm growth is adaptive and temporary (i.e., rather than genetic) [139]. A few factors could contribute to the increased tolerance to antibiotics. Similar to other bacterial species, NTM in biofilms are embedded within a ...
kinetics in erlotinib over a longer time period (2 weeks inFig. 1cversus 72 h inFig. 1b). As expected, PC9-1 cells experienced widespread cell death after treatment with erlotinib before settling into a persister state (∼9–14 days) characterized by drug tolerance and negligible growth...
Q1: What is drug addiction? A:Drug addiction, also known as substance use disorder, is a disease that affects a person’s brain and behavior, leading to an inability to control the use of legal or illegal drugs or medication. It’s characterized by intense and, at times, uncontrollable dr...
This is because the AUC value of a drug reflects its cell line growth inhibition, with lower values indicating sensitivity and higher values implying tolerance to the drug. Thus, a gene whose expression positively correlates with the AUC of a drug is predictive of resistance to that drug; ...
Active disease characterized by the presence of open pulmonary cavities in the lung parenchyma, composed of a wall filled with necrotic debris and high bacterial burden, leading to poor treatment outcome and increased person-to-person transmission. Drug tolerance Increased survival of bacterial cells in...
After 15 weeks of administration, all mice were subjected to oral glucose tolerance test (OGTT). After designated periods, mice were sacrificed for collecting serum and organs. Organ pieces were stored in RNA later (Invitrogen, USA) and frozen at −80 °C for further analysis. Sera were ...
Sertraline is an SSRI with high binding affinity to serotonin transporter that is mainly used to treat depression, obsessive-compulsive disorder, panic disorder, and social anxiety disorder, with a good tolerance and safety record. Sertraline's antitumor effects have been demonstrated in different types...