Histone Lys acetylation Covalent addition of an acetyl group to Lys residues of histones. Many Lys residues can be acetylated and, unlike methylation, acetylation changes the charge of the Lys. By masking the p
Structural analysis revealed that the bromodomains of Gcn5 or PCAF have a specific affinity for acetyl-lysine-containing motifs, including acetylated histone H4, suggesting that bromodomains can interact with chromatin, but also with other proteins in an acetylation-dependent manner [[60], [61], ...
Since the seminal finding that the histone acetylases and deacety-lases (18, 19) are transcriptional coregulators, intense and continuing efforts have been made to catalog the numbers and types of PTMs that occur to histones on the premise that other histone-modifying enzymes PAD4的角色在...
For example, even though p300 has intrinsic histone acetylase activity, it also behaves as a hub protein with an interaction network spanning hundreds of cellular proteins [84]. Therefore, through binding p300, E1A has access to an astonishing number of p300-associated proteins. Even within the...
Want to thank TFD for its existence?Tell a friend about us, add a link to this page, or visitthe webmaster's page for free fun content. Link to this page: Facebook Twitter Acronyms browser? ▲ PCA52S PCAA PCAAC PCAACA PCAAD