MGCD0103 is known as a histone deacetylase inhibitor. In this study, we investigated the effect of MGCD0103 on the in vitro blastocyst formation rate in porcine somatic cell nuclear transferred (SCNT) embryos and expression in acetylation of the histone H3 lysine 9 and histone H4 lysine 12. ...
Histone deacetylase inhibitors (HDACi) developed as anti-cancer agents have a high degree of selectivity for killing cancer cells. HDACi induce acetylation... JH Lee,ML Choy,L Ngo,... - 《Proceedings of the National Academy of Sciences of the United States of America》 被引量: 334发表: ...
(FISH).After hEF were treated with TSA or VPA,histone acetylation(acH4K12) and methylation(H4K20me1) were examined by using indirect immunofluorescence staining and scanning confocal microscopy.【Result】 There was difference between group of TSA treatment and group of non-TSA treatment in cell ...
市城市规划局批准建设的居住小区整体结构设计违反了国家的有关法律规定，给原告甲村的利益造成严重损害，但是房屋及其配套设施等已经建成交付使用。撤销批准建设的具体行政行为将会给公共利益造成重大损失，人民法院应当如何处理( )
Quantitative proteomics analyses reveal that stimulated histone acetylation peaks after six hours, but lysine lactylation peaks only at 24 hours, following glucose treatment Enhanced mitochondrial metabolism reduces lactate production and histone lactylation, while enhanced glycolysis increases lactate production...
We characterized the effect of histone acetylation on the structure of a nucleosome and the interactions between two nucleosomes. In this study, nucleosome... YL Ju,S Wei,TH Lee - 《Journal of Biological Chemistry》 被引量: 22发表: 2011年 Effects of Spermine and Its Cytotoxic Analogs on Nuc...
Combined Effect of Histone Acetylation and Acetyl Mark Readers on Radiation Sensitivity We are interested in studying potential drugs that have the ability to make tumors more sensitive to radiation. There has been much interest in examining t... BA Greenberger 被引量: 0发表: 2016年 Method and ...
The main mitochondrial-dependent signaling events: the release of mitochondrial ROS to induce the changes of gene expression through HIF/AMPK/Ca2+/Cn; release of metabolites to induce histone acetylation, histone and DNA demethylation, which determined cell differentiation; activation of AMPK regulates ...
Also, 2M4VP inhibited hyper-acetylation of histone H3 (Lys9/Lys14) induced by LPS. Taken together, our results suggest that 2M4VP, a naturally occurring phenolic compound, exert potent anti-inflammatory effects by inhibiting LPS-induced NO, PGE 2 , iNOS , and COX-2 in RAW264.7 cells. ...
The regulatory activities of proteins, such as activation or repression, are often associated with histone modifications4. For instance, the binding sites of an activator often coincide with the locations marked by histone acetylation. Hence, the set of histone modifications that typically mark the bi...