In mammals, HDACs can remove the acetylation from H3K27ac25,26. We are curious about whether HDACs are required for the transition of H3K27ac modifications from broad domains to narrow peaks during human embryo development. We firstly investigated the gene expression of HDACs in human early ...
Using M1 macrophages that have been exposed to bacteria as a model system, we show that histone lactylation has different temporal dynamics from acetylation. In the late phase of M1 macrophage polarization, increased histone lactylation induces homeostatic genes that are involved in wound healing, ...
This process, among others, is required for epigenomic remodeling and proper expression of developmental genes. Thus, histone lactylation has a similar function to acetylation, which has long been observed to enhance transcription of regions where it is deposited29,30. Given the chemical similarities...
Histone acetylation plays key roles in gene expression, but its effects on superoxide dismutase 1 (SOD1) expression in senile cataract remains unknown. To address this problem, the study was to investigate the influence of histone acetylation on SOD1 expression and its effects in the pathogenesis ...
Acetylation of nucleosome was performed as described previously39. Briefly, nucleosome and HATs were first incubated in 1:1 stoichiometry in reaction buffer containing 50 mM Tris-HCl (pH 8.0), 0.1 mM EDTA, 10% (v/v) glycerol, 1 mM DTT, 1 mM PMSF at 30 °C for 5 min,...
Histone acetylation and deacetylation are important epigenetic mechanisms that regulate gene expression and transcription. Histone deacetylase 6 (HDAC6) is a unique member of the HDAC family that not only participates in histone acetylation and deacetyla
However, the mechanism by which lactate exerts its effect remains elusive. Using RNA-seq and CUT&Tag chromatin profiling, we found that induction of hexokinase 2 (HK2) expression in activated HSCs is required for induced gene expression by histone lactylation but not histone acetylation. ...
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Histone acetylation is a predominant active chromatin mark deposited by histone acetyltransferases (HATs) that transfer the acetyl group from acetyl coenzyme A (acetyl-CoA) to lysine ε-amino groups in histones. GENERAL CONTROL NON-REPRESSED PROTEIN 5 (GCN5) is one of the best-characterized HATs ...
In this scenario, these pathways sense and integrate nutrient signals for the induction of coordinated gene expression programs in cancer. This...doi:10.1038/nrm.2017.61ZlotorynskiEytanNat Rev Mol Cell BiolNature Reviews Molecular Cell Biology