histone acetylation regulates gene expression at the epige-netic level.In this review,we summarized latest research on the classification of acetyltrans-ferases and deacetylases together with their functional characteristics regarding gene regula-tion in the eukaryotic model organism Saccharomyces cerevisiae...
This process, among others, is required for epigenomic remodeling and proper expression of developmental genes. Thus, histone lactylation has a similar function to acetylation, which has long been observed to enhance transcription of regions where it is deposited29,30. Given the chemical similarities...
Using M1 macrophages that have been exposed to bacteria as a model system, we show that histone lactylation has different temporal dynamics from acetylation. In the late phase of M1 macrophage polarization, increased histone lactylation induces homeostatic genes that are involved in wound healing, ...
Wang, C., Fu, M., Pestell, R.G. (2004). Histone Acetylation/Deacetylation As a Regulator of Cell Cycle Gene Expression. In: Lieberman, H.B. (eds) Cell Cycle Checkpoint Control Protocols. Methods in Molecular Biology™, vol 241. Humana Press. https://doi.org/10.1385/1-59259-646-...
Genome-Wide Integration on Transcription Factors, Histone Acetylation and Gene Expression Reveals Genes Co-Regulated by Histone Modification Patterns 来自 NCBI 喜欢 0 阅读量: 40 作者:Y Natsumekitatani,M Shiga,H Mamitsuka 摘要: N-terminal tails of H2A, H2B, H3 and H4 histone families are ...
The N-terminal tail of core histones undergoes different posttranslational modifications including acetylation, phosphorylation and methylation. These modifications occur in response to cell signal stimuli and have a direct effect on gene expression. In most species, the histone H2B is primarily acetylated...
To further investigate epigenetic regulation of SMN, we used chromatin immunoprecipitation to characterize the acetylation state of histones associated with the SMN promoter locus. We show that the SMN promoter has a reproducible pattern of histone acetylation conserved across species and tissues. ...
HDAC1 deacetylates p53 and modulates its effect on cell growth and apoptosis.Histone acetylation and deacetylation, catalyzed by multisubunit complexes, play a key role in the regulation of eukaryotic gene expression. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family...
Furthermore, in endometrium cancer cells, the treatment with both 5AzadC and TSA had a synergistic effect, restoring and up-regulating PR gene expression [35], [36]. However, the regulation of PR isoforms expression by DNA methylation and histone acetylation has not been reported in astrocytoma...
In this scenario, these pathways sense and integrate nutrient signals for the induction of coordinated gene expression programs in cancer. This...doi:10.1038/nrm.2017.61ZlotorynskiEytanNat Rev Mol Cell BiolNature Reviews Molecular Cell Biology