The combined inhibition of transcription and CBP/p300 further demonstrates that acetyltransferases remain active and continue to acetylate histones independently of transcription. Together, these results show that histone acetylation is not a mere consequence of transcription; acetyltransferase recruitment and ...
Therefore, we determined that artemisinin could pre protect PC12 cells by increasing the acetylation level of histone 3. At least, acetylation of histones is one such pathway by which artemisinin prevents Alzheimer's disease. Collectively all results showed a novel mechanism by which artemisinin ...
Histone acetylation is a predominant active chromatin mark deposited by histone acetyltransferases (HATs) that transfer the acetyl group from acetyl coenzyme A (acetyl-CoA) to lysine ε-amino groups in histones. GENERAL CONTROL NON-REPRESSED PROTEIN 5 (GCN5) is one of the best-characterized HATs ...
The results show that there is an increased degree of acetylation of histones in the liver of immature chicks as a result of oestradiol-17尾 administration. The change in the modification pattern of histones was found to be an early event, correlated with the time course of appearance of new...
of an acetyl group alters the positive charge of specific lysines, thus modifying the electrostatic properties of the proteins targeted by HATs. The protein chemical modification occurring following acetylation results in modified protein functions. Proteins modified by acetylation might be both of ...
S1a–c)7. A large percentage (80.3%) of peaks discovered by our method are also present in the published data (Supplementary Fig. S1d)7. The results suggest that our ChIP-seq method is robust. Using this method, we performed ChIP-seq assays for H3K27ac in human early embryos at the...
Histone acetylation plays an important role in the regulation of gene expression. Histones are proteins that bind to DNA in the nucleus and belong to a family of basic proteins of five main types: H1, H2A, H2B, H3, and H4 [5]. The primary function of histones is the formation of ...
Epigenetics is the reversible changes in gene expression without the changes of DNA sequences,which include DNA methylation,histone modification and non-coding RNA expression and so on.Histone acetylation is the earliest studied posttranslational modification of epigenetic regulations.The results suggest tha...
Nucleosome linking number change controlled by acetylation of histones H3 and H4. High levels of acetylation of lysines in the amino-terminal domains of all four core histones, H2A, H2B, H3, and H4, have been shown to reduce the linking ... VG Norton,KW Marvin,P Yau,... - 《Journal ...
The GSE3 gene encodes a histone acetyltransferase that binds histones and influences histone acetylation levels. GSE3 is recruited by the transcription factor GS2 to the promoters of their co-regulated grain-size genes and influences the histone acetylation status of their co-regulated genes. Field ...