In subject area: Biochemistry, Genetics and Molecular Biology Histone acetylation is characterized by the addition of an acetyl group from acetyl coenzyme A (acetyl-CoA) to the lysine amino group on the N-terminal of a histone via histone acetyltransferases (HATs). ...
AI generated definition based on:Current Opinion in Pharmacology,2010 About this page Set alert Chapters and Articles You might find these chapters and articles relevant to this topic. Histone acetylation and histone deacetylation in neuropathic pain: An unresolved puzzle?
Histone Acylation beyond Acetylation: Terra Incognita in Chromatin Biology. Cell journal 17, 1–6 (2015). 17. Schroder, S. et al. Acetylation of RNA polymerase II regulates growth-factor-induced gene transcription in mammalian cells. Molecular cell 52, 314–324 (2013). 18. Dias, J. D. ...
Post-translational modification of lysine groups on histone tails; Acetylation of nucleosomal histones; Histone code Definition Histoneacetylation defines a post-translational modification of histone proteins, which are the major component of the basic unit ofchromatincalled the nucleosome. Histone modification...
Histone lysine acylations by short-chain fatty acids are distinct from the widely studied histone lysine acetylation in chromatin, although both modifications are regulated by primary metabolism in mammalian cells. It remains unknown whether and how histone acylation and acetylation interact to regulate ...
Cervical carcinoma is one of the most common cancers among women globally. Histone deacetylase inhibitors (HDACIs) constitute anticancer drugs that, by increasing the histone acetylation level in various cell types, induce differentiation, cell cycle arr
Here, we present the global and gene-specific changes in histone acetylation in Arabidopsis explants that are undergoing SE. In the TSA (trichostatin A)-induced SE, we demonstrate that H3 and H4 acetylation might control the expression of the critical transcription factor (TF) genes of a vital...
Synonyms Lysine acetylation of histones Definition Histone acetylation is a reversible and covalent modification of histone proteins introduced at the ε-amino groups of lysine residues. Histones and DNA form a complex – chromatin – which condenses DNA and controls gene activity. Current models interp...
Definition Histone acetyltransferases comprise of a class of enzymes that catalyze the acetylation of histones, with consequences for chromatin structure and function. The activity of these enzymes is opposed by histone deacetylases. Chromatin Acetylation Polyglutamine Disease, the Emerging Role of ...