In subject area:Biochemistry, Genetics and Molecular Biology Histone acetylation is characterized by the addition of an acetyl group from acetyl coenzyme A (acetyl-CoA) to the lysine amino group on the N-terminal of a histone via histone acetyltransferases (HATs). ...
Biochemistry, Genetics and Molecular Biology Medicine and Dentistry Chapters and Articles You might find these chapters and articles relevant to this topic. Histone acetylation and histone deacetylation in neuropathic pain: An unresolved puzzle?
Histone Acylation beyond Acetylation: Terra Incognita in Chromatin Biology. Cell journal 17, 1–6 (2015). 17. Schroder, S. et al. Acetylation of RNA polymerase II regulates growth-factor-induced gene transcription in mammalian cells. Molecular cell 52, 314–324 (2013). 18. Dias, J. D. ...
Histone acetylation is generally associated with gene activation and chromatin decondensation. Recent mass spectrometry analysis has revealed that histone H4 lysine 20, a major methylation site, can also be acetylated. To understand the function of H4 lysine 20 acetylation (H4K20ac), we have develop...
Histone lysine acylations by short-chain fatty acids are distinct from the widely studied histone lysine acetylation in chromatin, although both modifications are regulated by primary metabolism in mammalian cells. It remains unknown whether and how histone acylation and acetylation interact to regulate ...
Cervical carcinoma is one of the most common cancers among women globally. Histone deacetylase inhibitors (HDACIs) constitute anticancer drugs that, by increasing the histone acetylation level in various cell types, induce differentiation, cell cycle arr
Figure S2: Effect of 4SC-202 on acetylation of H3k27Ac protein in vitro. Figure S3: Effect of 4SC-202 on cell-cycle distribution and apoptosis in human hFOB 1.19 cells. Figure S4: Assessment of RNA quality for 12 samples applied in RNA-seq analysis. Figure S5: RNA-seq analysis of ...
(also not present in any of the species); bromodomain-containing proteins, which read acetylation marks [97] (found in some cryptophyte nucleomorphs); chromodomain-containing proteins, which read lysine methylated residues [98] (none found in nucleomorphs); PHD finger proteins, readers of lysine...
Such modifications of the polypeptide include, but are not limited to, acetylation, carboxylation, glycosylation, phosphorylation, lipidation, and acylation. Post-translational processing which cleaves a "prepro" form of the protein may also be used to facilitate correct insertion, folding and/or ...
we found that the drug-resistance is associated with activation of AKT signaling pathway. Further study indicated that G9a activates the AKT signaling pathway by increasing the level of H3K9me2 in thePTENpromoter region and reducing acetylation, which leads to drug resistance [68]. In terms of ...