(1999) Engraftment of ex vivo-expanded cord blood cells in NOD/SCID mice: what is the clinical relevance? Blood, 93, 4445.McNiece, I.K. ( 1999 ) Engraftment of ex vivo -expanded cord blood cells in NOD/SCID mice: what is the clinical relevance? Blood , 93 , 4445 ....
Humanized mouse is a general term that refers to a mouse that has been engrafted with something from a human. ... But humanized mice can be even more powerful
Passive immunization with a human monoclonal antibody protects hu-PBL-SCID mice against challenge by primary isolates of HIV-1 How well antibodies can protect against disease due to HIV-1 infection remains a pivotal but unresolved issue with important implications for vaccine desig... MC Gauduin,PW...
et al. Complete reconstitution of human lymphocytes from cord blood CD34+ cells using the NOD/SCID/γcnull mice model. Blood 102, 873–880 (2003). Article CAS PubMed Google Scholar Lapidot, T. et al. A cell initiating human acute myeloid leukaemia after transplantation into SCID mice. ...
The boundaries have already been crossed, prompting creation of transgenic animals. Most such genetically engineered animals are mice or rats that had human genes of various kinds inserted into their genomes and counterpart rodent genes removed. For example, AIDS research has benefited greatly from cre...
(ADA) gene. By using a retroviral vector, the ADA gene was transferred into hematopoietic stem cells and then injected into patient's body. Severe complex immunodeficiency (SCID) caused by gene deficiency was successfully cured. The subsequent hemophilia B gene therapy research carried out by Xue...
Elimination of human leukemia cells in NOD/SCID mice by WT1-TCR gene-transduced human T cells Blood, 106 (9) (2005), pp. 3062-3067 View PDFView articleCrossrefView in ScopusGoogle Scholar 9 DL Porter, BL Levine, M Kalos, et al. Chimeric antigen receptor-modified T cells in chronic lym...
The growth and metastasis of human, HER-2/neu-overexpressing tumor cell lines in male SCID mice HER-2/neu is overexpressed on a variety of human adenocarcinomas and overexpression has been associated with a poor prognosis. For this reason, HER-2 has b... B Clinchy,A Gazdar,R Rabinovsky...
Gu, Y. et al. Growth retardation and leaky SCID phenotype of Ku70-deficient mice.Immunity7, 653–665 (1997). CASPubMedGoogle Scholar Samper, E., Goytisolo, F. A., Slijepcevic, P., van Buul, P. P. & Blasco, M. A. Mammalian Ku86 protein prevents telomeric fusions independently of...
T-cell responses are needed though, as shown by how susceptible those with HIV infection are to M. tuberculosis infection, or the rapidly progressive infections seen in SCID mice, as well as the increased mycobacterial growth in mice lacking the ability to produce or respond to IFNγ; in ...