当前，多数ADC药物的临床前评价是在免疫缺陷小鼠的异种移植模型中进行的，主要包括裸鼠、CB17-SCID小鼠、NOD-SCID小鼠及其衍生的NXG系列小鼠[2]。其中，NXG系列小鼠具有最严重的免疫缺陷，包括了NK细胞缺失及巨噬细胞、树突细胞功能缺陷，因此广泛用于肿瘤移植研究。然而，这些小鼠品系在ADC药效评价中的实际运用却存在较...
Cassie Baker Lee, Dennis Benjamin, Che-Leung Law. Fc-FcγR interaction impacts the clearance and antitumor activity of antibody-drug conjugates in NSG mice. [abstract]. In: Proceedings of the 107th Annual Meeting of the American Association for Cancer Research; 2016 Apr 16-20; New Orleans, ...
Cassie Baker Lee, Dennis Benjamin, Che-Leung Law. Fc-FcγR interaction impacts the clearance and antitumor activity of antibody-drug conjugates in NSG mice. [abstract]. In: Proceedings of the 107th Annual Meeting of the American Association for Cancer Research; 2016 Apr 16-20; New Orleans, ...
Diamanti P, Cox CV, Blair A: Comparison of childhood leukemia initiating cell populations in nod/scid and nsg mice. Leukemia 26(2):376-380 (2012).Diamanti P; Cox CV; Blair A.Comparison of childhood leuke- mia initiating cell populations in NOD / SCID and NSG mice.Leukemia.2012.376-380...
[7]Fu Li, Michelle Ulrich, Joshua Hunter, Lori Westendorf, Devra Olson, Cassie Baker Lee, Dennis Benjamin, Che-Leung Law. Fc-FcγR interaction impacts the clearance and antitumor activity of antibody-drug conjugates in NSG mice. [abstract]. In: Proceedings of the 107th Annual Meeting of ...
[7]Fu Li, Michelle Ulrich, Joshua Hunter, Lori Westendorf, Devra Olson, Cassie Baker Lee, Dennis Benjamin, Che-Leung Law. Fc-FcγR interaction impacts the clearance and antitumor activity of antibody-drug conjugates in NSG mice. [abstract]. In: Proceedings of the 107th Annual Meeting of ...
[7]Fu Li, Michelle Ulrich, Joshua Hunter, Lori Westendorf, Devra Olson, Cassie Baker Lee, Dennis Benjamin, Che-Leung Law. Fc-FcγR interaction impacts the clearance and antitumor activity of antibody-drug conjugates in NSG mice. [abstract]. In: Proceedings of the 107th Annual Meeting of ...
[7]Fu Li, Michelle Ulrich, Joshua Hunter, Lori Westendorf, Devra Olson, Cassie Baker Lee, Dennis Benjamin, Che-Leung Law. Fc-FcγR interaction impacts the clearance and antitumor activity of antibody-drug conjugates in NSG mice. [abstract]. In: Proceedings of the 107th Annual Meeting of ...
This mice strain lacks mature T and B lymphocytes and completely loses NK cell activity[78]. Compared with NOD/SCID mice, the transplantation survival rate of human cell and tissue in NSG mice is significantly improved, and at the same time, a higher proportion of normal or cancerous human...
mice or NOD/SCID/γc−/−mice (stock number 00557,NSG mice; The Jackson Laboratory). In comparison to other immunodeficient strains of mice like SCID, both NOD/SCID and NOD/SCID/γc−/−mice have a lower level of endogenousmousenatural killer (NK) cell activity which facilitates ...