Here, we present data on the transplantation of HSCs into NOD scid gamma (NSG) mice to achieve long-term engraftment without prior conditioning. We transplanted allogeneic HSCs constitutively expressing the mCherry fluorescent marker into age...
NSG mouse strain is an immunodeficient mouse that knocks out the interleukin 2 receptor gamma chain (IL2Rγ) gene on the basis of NOD/SCID[77]. From: Biochemical Pharmacology, 2022 About this pageSet alert Also in subject area: Biochemistry, Genetics and Molecular BiologyDiscover other topics...
The proliferation-inducing effect was not reflected in the spleen of engrafted mice; however, differentiation of T-cells was similar in vitro and in vivo. Cell batches which responded poorly in vitro were inert to IL-4 treatment after transplantation into NOD-scid IL2R γnull mice in vivo, ...
The recently described highly immunodeficient NOD/SCID/gamma null (NOG) mice provide a number of advantages. This strain, with life expectancy more than 90 weeks, is more robust than strains such as NOD/SCID and support generation of haematopoietic malignancies from transplanted human blast cells....
"Humanized mice," in which various kinds of human cells and tissues can be engrafted and retain the same functions as in humans, are extremely useful because human diseases can be studied directly. Using the newly combined immunodeficient NOD-scid IL2ry~(null) mice and Rag2~(null) IL2ry~(...
The NOD/SCID mice serve also as a preclinical model to study the phenotype of human leukemic stem cells, the SLICs, which mostly display a primitive, nondifferentiatedCD34+/CD38−expression profile. These cells extensively repopulate the BM of irradiated mice and initiate the disease similarly to...
Article: NOD-scid IL2R γnull mice engrafted with human peripheral blood mononuclear cells as a model to test therapeutics targeting human sig
Key words: immune reconstitution immunological therapy NOD/SCID mice triple-negative breast cancer 乳腺癌是女性中发病率高的癌症[1]。其中三阴乳腺癌(TNBC)以雌激素受体(ER)、孕激素受体(PR)和HER2/neu均为阴性表达,预后差[2-3]为特征。因缺乏针对性的治疗靶点,目前临床上结合手术的全身治疗只能依靠化疗。
NOD/SCID mice gradually become a useful tool for the study on Experimental Hematology.This paper comprehensively reviews the biological characteristics of NOD/SCID mice,the establishment of human leukemia model,stem cell transplantation,drug research,deficiency and improvement of NOD/SCID mice in applie...
6.Complete reconstitution of human lymphocytes from cord blood CD34+ cells using the NOD/SCID/gammacnull mice model.[J].Hidefumi;Hiramatsu;Ryuta;Nishikomori;Toshio;Heike;Mamoru;Ito;Kimio;Kobayashi;Kenji;Katamura;Tatsutoshi;Nakahata,Blood.2003,第3期 ...