Robinson SN, Simmons PJ, Thomas MW, Brouard N, Javni JA, Trilok S, Shim JS, Yang H, Steiner D, Decker WK, et al. 2012. Ex vivo fucosylation improves human cord blood engraftment in NOD-SCID IL-2Rgamma(null) mice
4.2.4 The NOD/LtSz-scid with IL2γcnull (NSG) mouse NSG mouse strain is an immunodeficient mouse that knocks out the interleukin 2 receptor gamma chain (IL2Rγ) gene on the basis of NOD/SCID[77]. This mice strain lacks mature T and B lymphocytes and completely loses NK cell activ...
IL2rgnull突变:Interleukin-2受体gamma链(IL-2Rγc,又称CD132)是具有重要免疫功能的细胞因子Il2、Il-4、Il-7、Il-9、Il-15和Il-21的共同受体亚基,该基因敲除后的小鼠机体免疫功能严重降低,通过多种受体阻断细胞因子信号传导,导致功能性NK细胞缺陷。 M-NSG严重免疫缺陷小鼠,缺失成熟T、B、NK细胞,可高效地植入...
The NOD.Cg-PrkdcscidIl2rgtm1Wjl/SzJ mouse strain, commonly known as NSG (for NOD SCID Gamma) is severely immunodeficient and thus is an excellent recipient for xenografts, and in particular for engrafting human tumor cells and human hematopoietic stem cells. In the latter case, these cells g...
2016. Attenuation of graft-versus-host-disease in NOD scid IL-2Rgamma(Ϫ/Ϫ) (NSG) mice by ex vivo modulation of human CD4(ϩ) T cells. Cytometry A 89:803- 815. https://doi.org/10 .1002/cyto.a.22930.Hilger N, Glaser J, Miiller C, et al. Attenuation of graft-versus-...
Choi B, Chun E, Kim M, Kim ST, Yoon K, et al. (2011) Human B Cell Development and Antibody Production in Humanized NOD/SCID/IL-2Rgamma(null) (NSG) Mice Conditioned by Busulfan . J Clin Immunol 31 : 253–264Choi B, Chun E, Kim M, Kim ST, Yoon K, Lee KY, Kim SJ. Human...
SUCCESSFULLY ESTABLISHMENT OF HUMANIZED NOD-SCID IL-2RγNULL (NSG) MICE BY INTRAHEPATIC INJECTION OF HUMAN UMBILICAL CORD BLOOD CD34+ CELLS: 1252An abstract is unavailable. This article is available as a PDF only.doi:10.1097/00007890-201007272-00878B. Choi...
(2011) Human B Cell Development and Antibody Production in Humanized NOD/SCID/IL- 2Rgamma(null) (NSG) Mice Conditioned by Busulfan. J Clin Immunol 31: 253-264.Choi, B. et al. Human B cell development and antibody production in humanized NOD/SCID/IL-2Rgamma(null) (NSG) mice ...
Human B cell development and antibody production in humanized NOD/SCID/IL-2Rgamma(null) (NSG) mice conditioned by busulfan. Journal of Clinical Immunology. 2011; 31:253-264. [PubMed: 20981478]Choi B, Chun E, Kim M, et al. Human B cell development and antibody production in humanized ...
Kang YK, Ko Y, Choi A, Choi HJ, Seo J-H, Lee M, Lee JA. Humanizing NOD/SCID/IL-2Rγnull (NSG) mice using busulfan and retro-orbital injection of umbilical cord blood-derived CD34 +cells. Blood Res. 2016;51(1):31. PMID: 27104189. doi:10.5045/ br.2016.51.1.31....