NSG mouse strain is an immunodeficient mouse that knocks out the interleukin 2 receptor gamma chain (IL2Rγ) gene on the basis of NOD/SCID[77]. This mice strain lacks mature T and B lymphocytes and completely l
Bruck F, Baron F, Dubois S, Briquet A, Hanon-Absil M, Belle L, et al. Rapamycin delays xenogeneic acute graft versus host disease (AGVHD) in NOD/SCID/Il2R gamma null (NSG) mice: impact of regulatory T cells. Biol Blood Marrow Transplant. 2011;17:S332....
NOD背景下Prkdcscid纯合突变:Prkdc(protein kinase, DNA-activated, catalytic polypeptide)基因主要编码DNA依赖性蛋白激酶(DNA-PK)的催化亚基,是参与双链DNA断裂修复、免疫球蛋白和T细胞受体可变(V)、多样性(D)、连接(J)区段重组的重要基因。Prkdcscid突变代表严重的联合免疫缺陷,表现为缺失T、B细胞,无法介导细胞和体...
SCID IL2rg skin transplantation humanized mice NOD/SCID NSG; 机译:SCID;IL2rg;皮肤移植;人源化小鼠;NOD / SCID;NSG; 入库时间 2022-08-21 11:28:51 相似文献 外文文献 中文文献 专利 1. Long-term maintenance of skin immune system in a NOD-Scid IL2r gamma(null) mouse model transplanted ...
摘要: Reduced phases of ultrathin rutile TiO(2)(110) grown on Ni(110) have been characterized with scanning tunneling microscopy and low-energy electron diffraction. Areas of 1 x 2 reconstruction are observed as well as {132} and {121} families of crystallographic shear planes. These phases ...
Humanized mouse models have become increasingly important and widely used in modeling human diseases in biomedical research. Immunodeficient mice such as NOD-Rag1-/-IL2RgammaC-null (NRG) or NOD-SCID-IL2RgammaC-null (NSG) mice are critical for efficient e
This PBMC engraftment model (termed Hu-PBL-SCID) has supported studies of human immune system-tumor interactions following injection of human PBMC into immunodeficient mice implanted with patient-derived (PDX) tumors. However, a major limitation of this model is the development of acute xenogeneic ...
Abstract 5665: NOD-scid IL2rgnull (NSG) mice deficient in murine MHC Class I and Class II expression support engraftment of functional human T cells in the absence of acute xenogeneic GVHD following injection of PBMCThe study of human immune system-tumor interactions has been limited historically...
Choi B, Chun E, Kim M, Kim ST, Yoon K, et al. (2011) Human B Cell Development and Antibody Production in Humanized NOD/SCID/IL-2Rgamma(null) (NSG) Mice Conditioned by Busulfan . J Clin Immunol 31 : 253–264Choi B, Chun E, Kim M, Kim ST, Yoon K, Lee KY, Kim SJ. Human...
2016. Attenuation of graft-versus-host-disease in NOD scid IL-2Rgamma(Ϫ/Ϫ) (NSG) mice by ex vivo modulation of human CD4(ϩ) T cells. Cytometry A 89:803- 815. https://doi.org/10 .1002/cyto.a.22930.Hilger N, Glaser J, Miiller C, et al. Attenuation of graft-versus-...