Naïve cells are non-active lymphocytes that recognize and bind to specific antigens, become activated, and launch target attacks against foreign pathogens.
Interleukin(IL producing CD4 Th9 cells are a unique subset of effector cells involved in both health and disease. Th9 cells have been associated with protective immunity during parasitic infections with helminths, protozoans and extracellular pathogens, but implicated in disease states such as ...
The Role of Regulatory T-cells in Transplantation Tolerance CD4+ Tregs have recently been categorized into "natural" and "adaptive."16 The "natural" Tregs are so called because they emerge from the thymus with the suppressive properties, are always present in normal individuals and mediate suppre...
Results The pathogenesis of MS is linked to the regulatory, inflammatory, suppressive, and effector roles of T cells. However, the actual roles of specific T cell subsets in MS development are not well understood. Discussion The study revealed a significant link between MS and T cell activity....
The presence of T cells with impaired function correlates with poor patient prognosis in several types of cancers and chronic infections.22 Effective immunotherapies can augment cancer-specific immunity by improving the effector cell functions of cytotoxic T cells or the antigen presentation capacity of ...
The characterization of tumor antigens recognized by immune effector cells has opened the perspective of developing therapeutic vaccines in the field of br... Curigliano,G. - 《Annals of Oncology》 被引量: 157发表: 2006年 T-cell-inducing vaccines - what's the future SummaryIn the twentieth ...
Some examples of viruses that have this effect and the innate defence mechanism that is diminished are listed in TABLE 1. Contribution by adaptive immune responses. Once adaptive immune effector cells are generated, these can contribute to tissue damage. T cells, for example, can directly destroy...
class I molecules (MHC-I) are cell surface recognition elements expressed on virtually all somatic cells. These moleculessample peptides generated within the cell and signal the cell's physiological state to effector cells of the immune system, both T lymphocytes and natural killer (NK) cells. ...
20 However, most of the adverse events (AE) were mild to moderate in severity.21 Related to the viral infections, IgE plays a central effector role in the pathophysiology of inflammatory diseases of the airways.20 The PROSE study evaluated whether treatment with omalizumab to reduce IgE would ...
Furthermore, a subset of CD8 + T cells (T effector ; Teff) was shown to be important in the development of AHR, allergic inflammation and IL-13. Although further investigations are necessary to fully understand the complex interactions between these inflammatory cells, mediators, cytokines and ...