The double life of a B-1 cell: self-reactivity selects for protective effector functions. Nat. Rev. Immunol. 11, 34–46 (2011). Article CAS PubMed Google Scholar Schiemann, B. et al. An essential role for BAFF in the normal development of B cells through a BCMA-independent pathway....
Maintaining homeostasis of the decidual immune microenvironment at the maternal–fetal interface is essential for placentation and reproductive success. Although distinct decidual immune cell subpopulations have been identified under normal conditions, systematic understanding of the spectrum and heterogeneity of ...
Specific antibody deficiency Not By definition Transient hypogammaglobulinemia of infancy Rarely Rarely Diseases of immune dysregulation Occasionally Occasionally Phagocytic cell defects Generally not Generally not Defects of innate immunity Defects of TLR signaling including NF-κB Generally not Often Other in...
CD8+granzyme B+ cells were examined to evaluate the effector cell phenotype of CD8+ T cells (Fig. 1I–K). As anticipated, higher density of CD8+granzyme B+ cells is significantly associated with better OS in both DCC (p = 0.007) and ICC (0.021) (Fig. 1I, K). However, CD8+...
Because TCRHh T cells that have recently experienced TCR stimulation are distributed throughout the LP and LA, whereas production of the Treg cell effector molecule IL-10 is highest in the LP, we examined the cellular interactions and/or molecular cues in the LP that drive TCRHh activation and...
Stress, and its consequent release of hormones and neurotransmitters, has been shown to influence specific immune parameters such as blood leukocyte numbers, NK cell activity, lymphocyte proliferation, antibody production, effector cell function, and CMI reactions. The immunoenhancing effects of stress ...
Single-cell T cell and B cell antigen receptor-sequencing data analysis can potentially perform in-depth assessments of adaptive immune cells that inform on understanding immune cell development to tracking clonal expansion in disease and therapy. However, it has been extremely challenging to analyze ...
(TTM) cells and CD45RA+CD45RO−CCR7−effector memory RA T (TEMRA) cells were identified in both CD4+and CD8+T cell compartments through manual gating (Extended Data Fig.1i,j). In addition, CD45RA−CD45RO+CD127−CD25+T regulatory (Treg) cells and CD45RA−CD45RO+PD1+CXCR5+...
[24]. TNBC patients have high TMB due to accumulation of genomic instability, which leads to the production neoantigens, thereby resulting in strong effector cell responses [25]. TNBC tumors have a “hot tumor phenotype”, which characterized by a high degree of immune infiltration and ...
In contrast, their oncologic counterparts had expanded effector memory and effector T-cell compartments (Figure 3K and Figure S7H). After stimulation with S peptides, and in contrast to healthy donors, cancer patients further expanded T-cells with effector phenotypes with a drastic reduction of ...