We conclude based on this analysis that N-MYC and WDR5 colocalize invariantly across cell lines at predicted sites of facilitated recruitment associated with protein synthesis genes. Surprisingly, we also identify N-MYC-WDR5 cobound genes that are associated with DNA repair and cell cycle ...
double-strand break repair via homologous recombinationcellular response to DNA damage stimulusspermatogenesissingle fertilizationmale gonad developmentprotein deubiquitinationmulticellular organism growthskin developmentembryonic organ developmentskeletal system morphogenesishomeostasis of number of cellspositive regulation ...
WD-repeats are motifs that are found in a variety of proteins and are characterized by a conserved core of 40-60 amino acids, which commonly form a tertiary propeller structure. While proteins that contain WD-repeats participate in a wide range of cellular functions, they are generally involved...