The value of ln(2) is approximately 0.693; thus, \\\({t_{{1 \\\mathord{\\\left/ {\\\vphantom {1 2}} ight. \\\kern-ulldelimiterspace} 2}}} \\\doteqdot {{0.693} \\\mathord{\\\left/ {\\\vphantom {{0.693} {{K_e}}} ight. \\\kern-ulldelimiterspace} {{K_e}}}...
This tutorial deals with basic concepts of volume of distribution, the second most important parameter in pharmacokinetics but often challenging for students in clinical pharmacology. Its relationships with dose, concentration and amount in the body are discussed using a physical model and examples of ...
apparent volume of distribution Pharmacology The ratio of the total amount of drug in the body to the concentration of the drug in the plasma, or the 'apparent' volume necessary to contain the entire amount of a drug, if the drug in the entire body were in the same concentration as in ...
Mahmood I: Prediction of clearance and volume of distribution in the obese from normal weight subjects: an allometric approach. Clin Pharmacokinet 2012; 51... DI Mahmood - 《Clinical Pharmacokinetics》 被引量: 19发表: 2012年 Prediction of Clearance and Volume of Distribution in the Obese from ...
pharmacokineticsfluoroquinolonesQSPRquantitative structure pharmacokinetic relationshipADME predictionMedicine(GeneralPharmacologyThe use of in silico approaches for successful prediction of pharmacokinetic properties of compounds during new drug discovery has been increasing exponentially. These in silico models, for ...
References in periodicals archive ?The volume of distribution, also known as the "apparent volume of distribution," quantifies how the drug disperses throughout the body. A primer on pharmacokinetics This value was normalized (N.CLT) by dividing App.CLT by the weight of the bird; the ...
2003. Prediction of human pharmacokinetics from animal data and molecular structural parameters using multivariate regression analysis: Volume of distribution at ... T Wajima,K Fukumura,Y Yano,... - 《Journal of Pharmacy & Pharmacology》 被引量: 0发表: 2003年 The prediction of human pharmacokinetic...
A two-volume model best described the pharmacokinetics of Ringer鈥檚 lactate solution. The mean arterial pressure (MAP) and body weight (WT) were significant covariates for the elimination clearance (kr) and central volume of distribution at baseline (Vc0), respectively. The parameter estimates ...
The nearly parallel decrease in total body clearance, with volume of distribution and nonrenal clearance remaining relatively constant, suggests that the same... R A,Blum,R K,... - 《Antimicrobial Agents & Chemotherapy》 被引量: 61发表: 1989年 Pharmacokinetics of ciprofloxacin and vancomycin in...
Journal of Pharmacokinetics & PharmacodynamicsWu X, Nekka F, Li J. 2016. Steady-state volume of distribution of two- compartment models with simultaneous linear and saturated elimina- tion. J Pharmacokinet Pharmacodyn 43:447- 459. https://doi.org/10 .1007/s10928-016-9483-z....