volume of distributionAuthor information: (1)Institute of Pharmacology, Faculty of Science, University of Pavia, Italy.doi:10.1006/phrs.1997.0131R F VillaA GoriniPharmacol RevPharmacological ReviewsVilla RF, Gorini A. Pharmacology of lazaroids and brain energy metabolism: a review. Pharmacol Rev. ...
Basic concept of pharmacokinetics 5.I (time-concentration curve) 5.2 (bioavailability) (F)= A (药入循药的药量) D (服药药量) x 100% 生物利用度= AUCiv/AUCpo×100% 利用度 5.3 (apparent volume of distribution,Vd) Vd= A / C C A L L/kg . 70kg : Vd 4L = 10-20L = 42L = >...
The Journal of pharmacy and pharmacologyC. K. Svensson. Relationship between antipyrine elimination rate constant, clearance and volume of distribution in the... CK Svensson - 《Journal of Pharmacy & Pharmacology》 被引量: 0发表: 2019年 Preparation and the in-vivo evaluation of paclitaxel liposomes...
With 54 new drugs and seven cellular and gene therapy products, the approvals by the US Food and Drug Administration (FDA) recovered 2023 from the 2022 dent back to the levels of 2020–2021. As in previous years of this annual review, we assign these new drugs to one of three levels o...
A recirculatory kinetic model was a good description of the acute kinetics of magnesium in sheep. The volume of distribution of magnesium in the lungs was 0.89 L, and in the body was 4.02 L. A permeability term (0.59 L min-1) described the distribution of magnesium into a deeper (...
The dominant paradigm in drug discovery is the concept of designing maximally selective ligands to act on individual drug targets. However, many effective drugs act via modulation of multiple proteins rather than single targets. Advances in systems biolo
The pharmacokinetic changes most consistently seen with aging occur in the volume of distribution, clearance, and half-life of a drug. Renal drug clearance is consistently diminished with aging. Hepatic metabolism is more variably affected, and in contrast to renal clearance, no reliable formula ...
After oral administration of total saponins at a dose of 500 mg/kg, the main non-compartmental parameters of the six analytes were calculated using DAS 3.2.8 software, including T1/2, Cmax, Tmax, AUC0−t, CLz/F, and apparent volume of distribution. The six analytes were quickly absorbed...
Japanese Journal of Pharmacology Open archiveArticles & IssuesVolume 82, Supplement 1 Pages 2-282 (2000) Previous vol/issue Next vol/issue Actions for selected articles Select all / Deselect allDownload PDFsExport citations select article Invited Lecture Conference abstractOpen archive Invited Lecture ...
Since the "arm" PBPK model depends on exchange in the "arm" muscle and it is assumed that the arm muscle has the same pharmacokinetic properties (partition coefficient, volume of distribution, flow/Kg etc.) as the whole body muscle, adjusting the muscle partition coefficient for the whole ...