Exploratory regressions on these data in children and previous data in adults showed fairly strong relationships between body size and tiagabine clearance and volume of distribution, with body size explaining about 40 to 50% of the variability. When adjusted per kg body weight, clearance and volume...
Apparent elimination half-life, volume of distribution and systemic blood clearance of propofol correlated strongly with the sampling period, which ranged from 8 to 52 h, depending on the time taken for the propofol concentration to reach the detection limit of the assay. In the three patients ...
Scientific Reports volume 13, Article number: 2096 (2023) Cite this article 2754 Accesses 12 Altmetric Metrics details Abstract Amyotrophic lateral sclerosis (ALS) is an inexorably progressive and degenerative disorder of motor neurons with no currently-known cure. Studies to determine the mechanism of...
(AUC), rate/percentage absorbed; volume of distribution; plasma or tissue protein binding; clearance rate or percentage excreted by kidneys, liver, lung etc Variable – Some TK parameters may be directly comparable; others require expert analysis of toxicokinetic profile Obtain data from experimental ...
Cryoprotectants accelerate water loss; however, excessive water loss causes shrinkage of cells below a lethal minimum volume [30]. The water permeability of cells is dependent on the cell type [31, 32]. The water permeability of MSCs and HUVECs is affected by their original in vivo environment...
(approximately 0.5 mL urine sample equivalent for CD9, 1 mL for LRRK2, and 2 mL for pSer1292-LRRK2) of each purified EV sample was incubated for 10 min at 95 °C in LDS sample buffer. The equivalent volume of each sample aliquot was loaded and separated on an SDS-...
(approximately 0.5 mL urine sample equivalent for CD9, 1 mL for LRRK2, and 2 mL for pSer1292-LRRK2) of each purified EV sample was incubated for 10 min at 95 °C in LDS sample buffer. The equivalent volume of each sample aliquot was loaded and separated on an SDS-...
Phosphatidylinositol 4,5-bisphosphate (PIP2) is required for successful completion of cytokinesis. In addition, both PIP2 and phosphoinositide-specific phospholipase C (PLC) have been localized to the cleavage furrow of dividing mammalian cells. PLC hydr
Screening 92,445 subjects in the Geisinger-Regeneron DiscovEHR cohort, we identified 5 patients heterozygous for nonsense mutations causing early terminations at Glu307 or Leu328 on the C-terminus of melanocortin 4 receptor (MC4R). Two Q307Ter carriers a
Body fat distribution, incident cardiovascular disease, cancer, and all-cause mortality. J Am Coll Cardiol. 2013;62:921–5. PubMed PubMed Central Google Scholar Download references Author information Authors and Affiliations Department of Pharmacology, Faculty of Medicine, University of Colombo, ...