Voltage-gatedcalciumchannels Voltage-gatedcalciumchannelsmediatecalciuminfluxinresponsetomembranedepolarisation andregulateintracellularprocessessuchascontraction,secretion,neurotransmission,and geneexpression.Theiractivityisessentialtocoupleelectricalsignalsinthecellsurfaceto physiologicaleventsincells.Theyaremembersofagenesuperfam...
Voltage-gated calcium channels (VGCCs) are membrane proteins and mediate Ca2+influx in response to membrane depolarization to evoke a wide spectrum of cellular responses, which include neurotransmitter release and activation of Ca2+-dependent enzymes. Molecularly, VGCCs are composed of multiple subunits...
Functional Studies of Trichoplax adhaerens Voltage-Gated Calcium Channel ActivityTrichoplax adhaerens is a member of the phylum Placozoa, an enigmatic group of benthic animals with remarkably simple morphology. While initial work on these organisms has primarily focused on their morphology and the ...
The structure and kinetics of calcium channels are extensive fields of study. It focuses on the potential opportunities for small-molecule intervention in neuronal signaling via antagonism of voltage-gated calcium channel subtypes, with a brief review of the chemotypes that have been recently reported ...
VOLTAGE-GATED CALCIUM CHANNEL MODULATION Voltage-gated calcium channels (VGCC), which are gated by the electrical potential across the plasma membrane, regulate the influx of Ca2 + ions. They have been subclassified as L, N, P and T channels. Low micromolar concentrations of THDOC, DHE...
Voltage-gated calcium channels (VGCCs) are membrane proteins and mediate Ca2+ influx in response to membrane depolarization to evoke a wide spectrum of cellular responses, which include neurotransmitter release and activation of Ca2+-dependent enzymes. Molecularly, VGCCs are composed of multiple subunit...
The cloned α1 subunit exhibits structural features common to voltage-gated cation channel gene families and is capable of directing expression of calcium channel activity in heterologous expression systems. In the central nervous system (CNS), VGCCs are expressed by five distinct a1 subunit genes (...
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Molecular insights into the gating mechanisms of voltage-gated calcium channel CaV2.3 Yiwei Gao, Shuai Xu, Xiaoli Cui, Hao Xu, Yunlong Qiu, Yiqing Wei, Yanli Dong, Boling Zhu, Chao Peng, Shiqi Liu, Xuejun Cai Zhang, Jianyuan Sun, Zhuo Huang & Yan Zhao Nature Communica...