Voltage-gated calcium channels are key sources of calcium entry into the cytosol of many excitable tissues. A number of different types of calcium channels have been identified and shown to mediate specialized cellular functions. Because of their fundamental nature, they are important targets for ...
Such a breadth of signaling variety results from an intricate combination of underlying variables66, including the field stimulation that can excite various parts of the neuron76, natural biological complexity involving the relative concentration and location of membrane voltage-gated calcium channels77,78...
ARTICLE https://doi.org/10.1038/s42003-021-01792-0 OPEN Voltage-gated proton channels from fungi highlight role of peripheral regions in channel activation Chang Zhao 1,2 & Francesco Tombola 1,2✉ Here, we report the identification and characterization of the first proton channels from fungi....
Such a breadth of signaling variety results from an intricate combination of underlying variables66, including the field stimulation that can excite various parts of the neuron76, natural biological complexity involving the relative concentration and location of membrane voltage-gated calcium channels77,78...
Clevidipine Voltage-gated calcium channels CaV1.2 Pannexin Dyspnea Hypertensive heart failure 1. Introduction Clevidipine is a 3rd generation dihydropyridine (DHP) that lowers blood pressure via selective antagonism of peripheral vascular smooth muscle (VSM) voltage-gated l-type calcium channels (CaV1.2) ...
It has been reported that four conserved glutamate residues, located at homologous positions in the putative pore-lining region (P-region) of each repeat of the α1 subunit, are molecular determinants for ion selectivity and ion permeation of voltage-gated Ca2+ channels (Yang et al., 1993, Ta...
Intracellular calcium transients generated by activation of voltage-gated calcium (CaV) channels generate local signals, which initiate physiological processes such as secretion, synaptic transmission, and excitation-contraction coupling. Regulation of calcium entry through CaV channels is crucial for control ...
In rat brain membranes, IbTX-D19Y/Y36F does not displace binding of [125I]MgTX or [125I]-alpha-DaTX to sites associated with voltage-gated K+ channels, nor do these latter toxins inhibit [125I]IbTX-D19Y/Y36F binding. Taken together, these results demonstrate that [125I]IbTX-D19Y...
voltage-gated Hv channels8,9(also known as VSOPs) and otopetrins10. In human, the Hv1 channel contributes to pH homeostasis in various cell types and has important functions in the immune, respiratory, and reproductive systems11, e.g., its activity is known to modulate the production of ...
We have characterized the effects of glu- cose on voltage-gated T-type Ca2ϩ channels and intracellular free calcium concentration, [Ca2ϩ]i in neonatal rat cardiomyo- cytes. We found that T-type Ca2ϩ channel current density in- creased significantly in primary culture neonatal cardiac ...