Synonyms α1G ; α1H ; α1I ; Cav3 ; T-type calcium channel Definition Low-voltage-activated (LVA) calcium channels are a class of voltage-gated calcium (Ca 2+ ) channels that exhibit a high probability of opening at hyperpolarized membrane voltages (negative to 50 mV). LVA channels ...
Activation of T cells is mediated by the engagement of T cell receptors (TCRs) followed by calcium entry via store-operated calcium channels. Here we have shown an additional route for calcium entry into T cells—through the low-voltage-activated T-type CaV3.1 calcium channel. CaV3.1 mediated...
Studies of voltage-gated potassium (Kv) channels have identified the S3b–S4 "paddle motif," which moves at the protein-lipid interface to drive channel opening, as the target for these amphipathic neurotoxins. Voltage-gated calcium (Cav) channels contain four homologous voltage sensor domains, ...
Identification of a disulfide bridge essential for structure and function of the voltage-gated Ca2+ channel α2δ-1 auxiliary subunit Voltage-gated calcium (CaV) channels are transmembrane proteins that form Ca2+-selective pores gated by depolarization and are essential regulators of the ... A Cald...
The reduced H2O2 production resulted in low calcium channel activity in the root cells. It is believed that H2O2 is required for the activation of calcium channels that in turn trigger the cellular calcium changes essential for cell growth in root hairs and possibly also in other root cells. ...
Structural Conservation of the Pores of Calcium-activated and Voltage-gated Potassium Channels Determined by a Sea Anemone Toxin The structurally defined sea anemone peptide toxins ShK and BgK potently block the intermediate conductance, Ca-activated potassium channel , a well recogn... H Rauer,M Pen...
Electromagnetic fields act via activation of voltage-gated calcium channels to produce beneficial or adverse effects 2013, Journal of Cellular and Molecular Medicine Extremely low-freauency electromagnetic fields promote in vitro neurogenesis via upregulation of Ca<inf>v</inf>1-channel activity 2008, ...
Cav1.4 channel openings occurred infrequently and were of brief duration. Moreover, openings occurred throughout the duration of the test depolarization, indicating that the slow inactivation kinetics observed at the whole-cell level are caused by sustained channel activity. Cav1.4 and Cav1.2 channels...
MEP depression occurs only in hand muscles supplied by the stimulated median nerve but not in those supplied by the ulnar nerve (Weise et al, 2006), and can be abolished by the NMDAR antagonist dextromethorphan and the voltage gated calcium channel blocker nimodipine (Wolters et al, 2003). ...
(see Supplementary Information for details. For recording of single channel activity of cell-attached patches of Xenopus oocyte membrane (Fig. S2C and D) the pipette was filled with (in mM): BaCl, 100; Hepes, 5; pH adjusted to 7.2 with NaOH, and the depolarizing bath solution ...