CaV3 (T-type) VGCCs activate at subthreshold potentials, and for example play an important role in generating rhythmic activity.Handbook of Neurochemistry and Molecular Neurobiologydoi:10.1007/978-0-387-30370-3_29M. WakamoriK. Imoto
The cloned α1 subunit exhibits structural features common to voltage-gated cation channel gene families and is capable of directing expression of calcium channel activity in heterologous expression systems. In the central nervous system (CNS), VGCCs are expressed by five distinct a1 subunit genes (...
CaV1 (L-type) VGCCs are involved also in inducing changes in gene expression. CaV3 (T-type) VGCCs activate at subthreshold potentials, and for example play an important role in generating rhythmic activity. 展开 关键词:SNAILS SPECIATION DISTRIBUTION DIVERSITY ...
The role of voltage-gated calcium channels in neurotransmitter phenotype specification: Coexpression and functional analysis in Xenopus laevis 喜欢 0 阅读量: 16 作者:Miller,E L.,Herbst,A W.,Lewis,B B.,Saha,S M.摘要: Calcium activity has been implicated in many neuro 关键词:...
L-type calcium channel activity is significantly reduced in both excitatory and inhibitory neurons in Ahnak KO mice, and L-type calcium channel influx is known to regulate neuronal excitability [19, 64, 65]. Thus, the opposing behavioral phenotype is presumably caused by a decrease or an increas...
However, the development of calcium channel antagonists as safe and selective therapeutics relies on the discovery of compounds that antagonize only the aberrant channel activity while sparing normal neuronal function. A refined understanding of the pharmacology associated with this target class results ...
Voltage-gated calcium channels are involved in a large variety of cellular functions such as excitation-contraction coupling, hormone secretion. firing and pacemaker activity, gene activation and proliferation. Cloning of complementary DNAs encoding for calcium channel subunits has challenged the study of...
In order to determine whether: a particular test compound is selective for class E channels, calcium channel activity can be measured in several cell types, each selected for its relative uniformity of voltage-sensitive ion channels: The anterior pituitary cell line, GH3, has both L-type and T...
From these studies a molecular picture of the structural elements important for the activity of voltage-gated ion channels has been established. This has assisted in clarifying the molecular basis of the electrical excitability of cells. 展开
(e. g., a domain), the protein will aggregate with other constituent domains in the membrane to form a functional channel. Thus, the presence of the protein can be detected by assaying the cell for T-type calcium channel activity. Indeed, assaying for channel activity serves to determine ...