For the most part, the effect of the subunits on the electrophysiology of voltage-gated calcium channels is to downregulate calcium channel activity by causing a hyperpolarizing shift in the inactivation curve. This finding and the association of these subunits with AMPA receptor trafficking has led...
The cloned α1 subunit exhibits structural features common to voltage-gated cation channel gene families and is capable of directing expression of calcium channel activity in heterologous expression systems. In the central nervous system (CNS), VGCCs are expressed by five distinct a1 subunit genes (...
The Cav subunit is the target for pharmacological agents that block (and in some cases enhance) calcium channel activity (Zamponi et al., 2015). This is relevant in the context of therapeutics, as calcium channel inhibitors have been used to treat disorders such as hypertension, pain and epile...
CaV1 (L-type) VGCCs are involved also in inducing changes in gene expression. CaV3 (T-type) VGCCs activate at subthreshold potentials, and for example play an important role in generating rhythmic activity. 展开 关键词:SNAILS SPECIATION DISTRIBUTION DIVERSITY ...
Voltage-gated calcium channels (VGCCs) are a large and functionally diverse group of membrane ion channels ubiquitously expressed throughout the central and peripheral nervous systems. VGCCs contribute to various physiological processes and transduce electrical activity into other cellular functions. This ...
Voltage-gated calcium ion (CaV) channels convert neuronal activity into rapid intracellular calcium signals to trigger a myriad of cellular responses. Thei... D Lipscombe,SE Allen,CP Toro - 《Trends in Neurosciences》 被引量: 162发表: 2013年 Differential distribution of voltage-gated calcium chann...
L-type calcium channel activity is significantly reduced in both excitatory and inhibitory neurons in Ahnak KO mice, and L-type calcium channel influx is known to regulate neuronal excitability [19, 64, 65]. Thus, the opposing behavioral phenotype is presumably caused by a decrease or an increas...
Ahnak1 is a tuneable modulator of cardiac Ca(v)1.2 calcium channel activity J. Muscle Res. Cell Motil., 32 (4–5) (2011), pp. 281-290 CrossrefView in ScopusGoogle Scholar [58] J. Wong, et al. Nanoscale distribution of ryanodine receptors and caveolin-3 in mouse ventricular myocytes:...
Neuropathic pain (NP) is a chronic pain caused by injury or disease of the somatosensory nervous system, or it can be directly caused by disease. It often presents with clinical features like spontaneous pain, hyperalgesia, and dysesthesia. At present, voltage-gated calcium ion channels (VGCCs...
However, the development of calcium channel antagonists as safe and selective therapeutics relies on the discovery of compounds that antagonize only the aberrant channel activity while sparing normal neuronal function. A refined understanding of the pharmacology associated with this target class results ...