virtual memory CD8 T cellsCancer cells can evade immune recognition by losing major histocompatibility complex (MHC) class I. Hence, MHC class I-negative cancers represent the most challenging cancers to treat. Chemotherapeutic drugs not only directly kill tumors but also modulate the tumor immune ...
A population of virtual memory CD8 T (CD8 TVM) cells underwent marked expansion upon infection with the helminth Heligmosomoides polygurus by an IL-4-regulated, antigen-independent mechanism. CD8 TVM cells disseminated to secondary lymphoid organs and established a major population of the systemic ...
Virtual memory CD8 T cells display unique functional properties Previous studies revealed the existence of foreign antigen-specific memory phenotype CD8 T cells in unimmunized mice. Considerable evidence suggests this p... JY Lee,SE Hamilton,AD Akue,... - 《Pnas》 被引量: 63发表: 2013年 The ...
Hussain, T. & Quinn, K. M. Similar but different: virtual memory CD8 T cells as a memory‐like cell population. Immunol. Cell Biol. 97, 675–684 (2019). CAS PubMed Google Scholar Ghanem, E. N. B., Nelson, C. C. & D’Orazio, S. E. T cell-intrinsic factors contribute to ...
Memory CD8(+) T cells are an important component of the adaptive immune response against many infections, and understanding how Ag-specific memory CD8(+) T cells are generated and maintained is crucial for the development of vaccines. We recently reported the existence of memory-phenotype, Ag-sp...
Similar but different: virtual memory CD8 T cells as a memory-like cell population 2019, Immunology and Cell Biology Memory T cells in flavivirus vaccination 2018, Vaccines Clonally expanded γδ T cells protect against Staphylococcus aureus skin reinfection 2018, Journal of Clinical Investigation Anti...
T-cell activation with an optimized binding peptide. The results from the T-cell activation assay revealed that binding acyclovir did not activate T-cells. Notably, both in silico models used crystal 3UPR (peptide P3 or M3) to conduct virtual screening, but our docking platform also included ...
Regulatory T cells limit unconventional memory to preserve the capacity to mount protective CD8 memory responses to pathogens virtual memory T cellsIL-15virus infectionImmunological memory exists so that following infection an expanded population of pathogen-specific lymphocytes can ... ASD Costa,JB Graha...
One such cell is the virtual memory CD8 T (TVM) cell, which is a semi‐differentiated but antigen‐na?ve CD8 T‐cell population. This review will summarize current knowledge of how TVM cells are generated, their memory‐like hallmarks, how they are maintained during steady state, infection ...
Phase I Study of Adoptive T-Cell Therapy Using Antigen-Specific CD8+ T Cells for the Treatment of Patients With Metastatic Melanoma PURPOSE: The adoptive transfer of in vitro generated tumor antigen-specific cytotoxic T lymphocytes (CTL) provides a promising approach to the immunotherap... A Mack...