Deep mutational scanning of Enterovirus A71 maps and quantifies the impact of genomic insertions, deletions and substitutions on virus fitness and highlights the role of insertions and deletions in the diversification of RNA viruses. William Bakhache ...
RNA species, such as (1) 5′-triphosphate with secondary structured RNAs25, (2) 5′-diphosphate uncapped RNAs26, and (3) RNAs with an unmethylated 5′-end nucleotide at the 2′-O position27,28, which are typically generated during replication of RNA viruses, including coronaviruses (Fig....
Many viruses, with distinct replication strategies, activate DNA-damage response pathways, including the lentivirus human immunodeficiency virus (HIV) and the DNA viruses EpsteinBarr virus (EBV), herpes simplex virus 1, adenovirus and SV40. DNA-damage response pathways involving DNA-dependent protein ki...
Virus:Host Cell Interactions Immune Response Host Cell Response Viral Replication RNA Production Tracking and Monitoring Viral Activity in Cells Promega technologies are used in studies monitoring key steps in viral pathogenesis, including detecting virus interactions with host cell surface receptors, ...
Numerous studies have reported that protein phosphorylation is crucial for several steps of the life cycle of different viruses and that specific host protein kinases are hijacked by viruses to promote infection [2,3,4]. In fact, these proteins have been pinpointed as potential host-directed ...
Functional analysis of viral RNA and protein-RNA interactions involved in the replication of poliovirus type 3null Poliovirus. RNA viruses. Picornaviruses... IR Dry - 《University of Glasgow》 被引量: 0发表: 2004年 Bovine Viral Diarrhea Virus Genome Modulates Translation as well as Replication of...
Replication competent HIV-1 viruses that express intragenomic microRNA reveal discrete RNA-interference mechanisms that affect viral replication. Cell Biosci. 2011; 1 :38. doi: 10.1186/2045-3701-1-38. [ Cross Ref ]Klase, Z., Houzet, L., and Jeang, K. T. (2011) Replication competent ...
Viruses can be classified based upon their genome structure and replication strategy (Fig. 1), with significantly different genes encoded from one family to another. Even among RNA viruses, only a single gene product is shared between all known members, the RdRp, responsible for copying viral ...
Medicinal plants produce a variety of bioactive constituents that have the abilities to inhibit the replication cycle of various types of DNA or RNA viruses like HIV, HSV, Influenza virus, Human rhinovirus, Hepatitis B and C virus (HBV and HCV), and Dengue virus. Throughout the globe, medici...
Sala et al. report the first structural snapshot of the Nipah virus RNA-dependent RNA polymerase in the actively elongating state, uncovering key mechanisms of RNA synthesis by non-segmented negative strand RNA viruses. Fernanda A. Sala