Von Hipple-Lindau gene (VHL) inactivation represents the most frequent abnormality in clear cell renal cell carcinoma (ccRCC). Hypoxia-inducible factor-1a (HIF-1alpha) expression is regulated by O_2 level. In normal O_2 conditions, VHL binds HIF-1a and allows HIF-1a prote-asomal degradation...
These results indicate a secondary role for P402 in the HIF-1alpha-VHL interaction. Elucidating the details of P402's role in the interaction of HIF-1alpha with VHL will enhance the understanding of mammalian oxygen sensing and ubiquitin-proteasome pathways.Halnin, Carlo de Guzman...
THE RELATIONSHIP OF EPO OVER-EXPRESSION TO VHL MUTATIONS AND Hif1α AND 2α IN SCCRCCPhosphodiesterase type 5 (PDE5) inhibitors effectively enhance the erectile function of the patients with erectile dysfunction (ED). The use of sildenafil citrate is expanding to a broader extent. Pulmonary ...
Wang YQ, Luk JM, Ikeda K, Man K, Chu AC, et al. (2004) Regulatory role of vHL/HIF-1alpha in hypoxia-induced VEGF production in hepatic stellate cells. Biochem Biophys Res Commun 317: 358-362.Wang Y Q,Luk J M,Ikeda K,et al.Regulatory role of vHL/HIF-1α in hypoxia-induced ...
The prevention of the interaction between E3 ligase VHL and HIFp-1 alpha may improve tolerance to hypoxia and ameliorate the prognosis of many diseases. To obtain novel potent inhibitors of VHL/HIF-1 alpha interaction, a series of hydroxyprolinep-based inhibitors were investigated for structural ...
Tovar-Castillo LE,Cancino-Diaz JC,Garcia-Vazquez F,Cancino-Gomez FG,Leon-Dorantes G,Blancas-Gonzalez F,Jimenez-Zamudio L,Garcia-Latorre E,Cancino-Diaz ME.Under-expression of VHL and over-expression of HDAC-1, HIF-1 alpha, LL-37, and IAP-2 in affected skin biopsies of patients with ...
Reports that hypoxia-inducible factor-1-alpha (HIF-1a) binding to von Hippel-Lindau tumor repressor protein (VHL) is regulated by stimulus-sensitive proline hydroxylation. Ability of VHL to recognize HIF-1a under normoxic conditions; Results indicating that proline hydroxylation is the primary ...
Paltoglou S, Roberts BJ (2007) HIF-1alpha and EPAS ubiquitination mediated by the VHL tumour suppressor involves flexibility in the ubiquitination mechanism, similar to other RING E3 ligases. Oncogene 26:604–609Paltoglou S, Roberts BJ (2007) HIF-1alpha and EPAS ubiquitination mediated by the...
Kamura T, Sato S, Iwai K, Czyzyk-Krzeska M, Conaway RC, Conaway JW (2000). Activation of HIF1alpha ubiquitination by a reconstituted von Hippel - Lindau (VHL) tumor suppressor complex. Proc Natl Acad Sci USA. 97:10430 - 10435....
The VHL protein recruits a novel KRAB-A domain protein to repress HIF-1alpha transcriptional activityHIF-1