Von Hipple-Lindau gene (VHL) inactivation represents the most frequent abnormality in clear cell renal cell carcinoma (ccRCC). Hypoxia-inducible factor-1a (HIF-1alpha) expression is regulated by O_2 level. In normal O_2 conditions, VHL binds HIF-1a and allows HIF-1a prote-asomal degradation...
These results indicate a secondary role for P402 in the HIF-1alpha-VHL interaction. Elucidating the details of P402's role in the interaction of HIF-1alpha with VHL will enhance the understanding of mammalian oxygen sensing and ubiquitin-proteasome pathways.Halnin, Carlo de Guzman...
THE RELATIONSHIP OF EPO OVER-EXPRESSION TO VHL MUTATIONS AND Hif1α AND 2α IN SCCRCCPhosphodiesterase type 5 (PDE5) inhibitors effectively enhance the erectile function of the patients with erectile dysfunction (ED). The use of sildenafil citrate is expanding to a broader extent. Pulmonary ...
It has been well shown that HIF-1 acts as a master regulator for hypoxic responses. So in the second chapter of this dissertation, I investigated the role of HIF-1alpha in endothelial cells. This dissertation has demonstrated that HIF-1alpha is critical for tumor and wound angiogenesis by ...
Reports that hypoxia-inducible factor-1-alpha (HIF-1a) binding to von Hippel-Lindau tumor repressor protein (VHL) is regulated by stimulus-sensitive proline hydroxylation. Ability of VHL to recognize HIF-1a under normoxic conditions; Results indicating that proline hydroxylation is the primary ...
The VHL protein recruits a novel KRAB-A domain protein to repress HIF-1alpha transcriptional activityHIF-1
The VHL protein recruits a novel KRAB-A domain protein to repress HIF-1alpha transcriptional activity. Embo J. 2003; 22 :1857–1867. doi: 10.1093/emboj/cdg173. [ Cross Ref ]Li Zaibo,Wang Dakun,Na Xi,Schoen Susan R,Messing Edward M,Wu Guan.The VHL protein recruits a novel KRAB-A ...
The prevention of the interaction between E3 ligase VHL and HIFp-1 alpha may improve tolerance to hypoxia and ameliorate the prognosis of many diseases. To obtain novel potent inhibitors of VHL/HIF-1 alpha interaction, a series of hydroxyprolinep-based inhibitors were investigated for structural ...
Osteogenic differentiationp-VHL/HIF-1 alpha/VEGF signaling pathwaySafflower yellowObjective: Safflower yellow (SY) is an active component ofCarthamus tinctorius L. that is widely used in orthopedics. This study aimed to evaluate the role of SY in angiogenesis and osteogenic differentiation.Biomedicine ...
HIF1 alphaKaplan-Meier survival analysisBladder carcinomaPurpose Our study was aimed to understand the importance of LIMD1-VHL-HIF1 alpha pathway in development of bladder carcinoma (BlCa) in association with arsenic prevalence.Basu, MuktaSSKMChatterjee, Amvrin...