别名 2-Propylpentanoic acid CAS 99-66-1 分子式 C8H16O2 分子量 144.21 储存条件 常温 纯度 Purity≥98% 单位 瓶 生物活性 Valproic acid 是一种 HDAC 抑制剂,IC50 值为 0.5-2 mM,抑制 HDAC1 的活性,(IC50,400 μM),同时可诱导 HDAC2 的降解;Valproic acid抑制VEGF,VEGFR2和bFGF的mRNA和蛋白质表达。
We aimed to determine to what extent elevated serum levels of valproic acid (VPA) and carbamazepine (CBZ) correlate with laboratory indications of end-organ dysfunction. METHODS :We reviewed a consecutive sample of patients 0-18 years of age who, over a 2-year period, had at least one ...
RESULTS & CONCLUSION The combination of carbapenems and valproic acid may lead to decrease the serum concentration of valproic acid significantly, clinical pharmacists advised to adjust antiepileptic drugs, anti-infective drugs or strengthen monitoring patients in clinical to obtain the good treatment ...
基本信息 中文名称:Valproic Acid Impurity 5 英文名称:Valproic Acid Impurity 5 EINECS:221-696-4 中文同义名: 二烯丙基丙二酸二乙酯; 二烯丙基丙二酸二乙酯,98%; 英文同义名: Diethyl 2,2-diallylmalonate , Tech.; 2,2-(Diallyl)malonic acid diethyl ester; Di-2-propenylpropanedioic acid diethyl es...
中文名称:Valproic Acid Impurity 19 英文名称:Valproic Acid Impurity 19 中文同义名: 丙基丙二酸; 2-丙基丙二酸; 丙戊酸钠杂质19; 英文同义名: ALPHA-PROPYLMALONIC ACID; AURORA KA-4358; RARECHEM AM LA 0045; PROPYLMALONIC ACID; 1,1-Butanedicarboxylicacid; 2-Propylmalonic acid; 2-Propylmalonicacid...
A clinical study with epilepsy patients receiving valproic acid (n = 35) showed that, after correction for hematocrit (HCT), plasma concentrations can be successfully calculated from the DPS quantification results. Passing〣ablok regression coefficients showed no proportional bias between estimated and ...
Results Valproic acid exhibits dose-dependent cytotoxicity in budding yeast To identify the optimal dose of VA and pursue further, we performed a growth assay with different commonly used laboratory Wild-type (WT) yeast cells. Interestingly, VA exhibited dose-dependent growth inhibition, but the effe...
Microglial abnormality and heterogeneity are also seen in animal models of ASD. Prenatal valproic acid (VPA) exposure changed microglial phenotypes from resting to activated states in the prefrontal cortex and hippocampus regions of infant and adolescent VPA model rats, but microglial activation was alle...
基本信息 中文名称:Valproic Acid Impurity I 英文名称:Valproic Acid Impurity I EINECS:236-338-2 中文同义名: 2-丙基戊腈; 双丙戊酸钠杂质D; 丙戊酸钠杂质I; 英文同义名: PENTANENITRILE, 2-PROPYL-; 2-PROPYLVALERONITRILE; 2-Propylpentanenitrile; Ai3-18232; Einecs 236-338-2; Sodium Valproate Impurit...
The protein level of CCN1 was quantified by using Image Lab software and normalized by the protein level of GAPDH. The results are representative of three independent experimental trials, and the values represent mean ± SD of the fold changes relative to the control at 0 min of time points ...