别名 2-Propylpentanoic acid CAS 99-66-1 分子式 C8H16O2 分子量 144.21 储存条件 常温 纯度 Purity≥98% 单位 瓶 生物活性 Valproic acid 是一种 HDAC 抑制剂,IC50 值为 0.5-2 mM,抑制 HDAC1 的活性,(IC50,400 μM),同时可诱导 HDAC2 的降解;Valproic acid抑制VEGF,VEGFR2和bFGF的mRNA和蛋白质表达。
Valproic acid (VPA) is a class I and IIa HDACi and, therefore, may be useful in anticancer therapy. VPA has been reported as a chemo-preventive epigenetic agent in individuals with high-risk oral dysplasia (OD) and thus associated with a reduced risk of HNSCC. It is hy...
Valproic acid (VPA) dosing needs to individualized for epilepsy patients through therapeutic drug monitoring (TDM). The patients must show up in the clinic at the therapeutic window time to venipuncture sample. Dried plasma spot (DPS) sampling is an alternative way to replace conventional veni...
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基本信息 中文名称:Valproic Acid Impurity 19 英文名称:Valproic Acid Impurity 19 中文同义名: 丙基丙二酸; 2-丙基丙二酸; 丙戊酸钠杂质19; 英文同义名: ALPHA-PROPYLMALONIC ACID; AURORA KA-4358; RARECHEM AM LA 0045; PROPYLMALONIC ACID; 1,1-Butanedicarboxylicacid; 2-Propylmalonic acid; 2-Propylma...
基本信息 中文名称:Valproic Acid Impurity 5 英文名称:Valproic Acid Impurity 5 EINECS:221-696-4 中文同义名: 二烯丙基丙二酸二乙酯; 二烯丙基丙二酸二乙酯,98%; 英文同义名: Diethyl 2,2-diallylmalonate , Tech.; 2,2-(Diallyl)malonic acid diethyl ester; Di-2-propenylpropanedioic acid diethyl es...
Valproic acid (VA) is a pharmacologically important histone deacetylase inhibitor that recently garnered attention as an anticancer agent. Since the molecular mechanisms behind the multiple effects of VA are unclear, this study was aimed to unravel the c
Microglial abnormality and heterogeneity are also seen in animal models of ASD. Prenatal valproic acid (VPA) exposure changed microglial phenotypes from resting to activated states in the prefrontal cortex and hippocampus regions of infant and adolescent VPA model rats, but microglial activation was alle...
中文名称:Valproic Acid Impurity I 英文名称:Valproic Acid Impurity I EINECS:236-338-2 中文同义名: 2-丙基戊腈; 双丙戊酸钠杂质D; 丙戊酸钠杂质I; 英文同义名: PENTANENITRILE, 2-PROPYL-; 2-PROPYLVALERONITRILE; 2-Propylpentanenitrile; Ai3-18232; Einecs 236-338-2; Sodium Valproate Impurity I; ...
tonsil-derived mesenchymal stem cells (TMSCs); valproic acid (VPA); CCN1; osteogenesis1. Introduction Tonsil-derived mesenchymal stem cells (TMSCs) are multipotent MSCs that have increasingly been studied due to their relatively high proliferation rate and low allogenicity compared to other tissue-...