Hamilton RA, Garnett WR, Kline BJ (1981) Determination of mean serum level by assay of a single pooled sample. Clin Pharmacol Ther 29:250–251Hamilton RA, Garnett WR, and Kline BJ (1981) Determination of mean valproic acid serum levels by assay of a single pooled sample. Clin Pharmacol...
A single assay of this sample provides the mean serum level of the testing period. The method was successfully tested with amaranth and then applied to valproic acid serum levels. AUC and mean serum levels were determined by the standard procedure of assays of multiple samples and the ...
She had been taking valproic acid, due to a previous episode of epileptic seizures, and presented with drowsiness and dizziness. ... RG Carretero,MR Brugera,M Olid-Velilla,... - 《Bmj Case Rep》 被引量: 2发表: 2016年 Valproic Acid Induced Thrombocytopenia and Dysmegakaryopoiesis in a ...
The abnormality rate of laboratory indexes in different age groups after long term VPA; VPA: Valproic acid. a-g different test trends. a the trend of variation of ALT levels in different age groups. b the AST levels decreased as age increased. P < 0.001. c the trend of variation of...
This older group of patients should be closely monitored during treatment with Valproic Acid Capsules for the development of acute liver injury with regular clinical assessments and serum liver test monitoring. The drug should be discontinued immediately in the presence of significant hepatic dysfunction,...
Carbamazepine and valproic acid: effects on the serum lipids and liver functions in children We aimed to determine the effects of carbamazepine, which induces liver microsomal enzymes, and valproic acid on the serum lipids and liver function test r... SE Dirik - 《Pediatric Neurology》 被引量:...
Valproic acid, a simple branched-chain fatty acid, was originally developed for the treatment of epilepsy, but also has mood-stabilising, anxiolytic, antimigraine and antinociceptive effects, and has been evaluated in the management of various other disorders, particularly psychiatric conditions. ...
Valproic acid (VPA), an anticonvulsant medication that has been shown to increase the risk of autism in humans, has become the standard for inducing a model of autism in animals. Some pathologies modeled in animals have been reversed using environmental enrichment paradigms. 84 Sprague-Dawley rats...
Valproic acid drug interactions (more detail)Test InteractionsMay cause a false-positive result for urine ketones (valproate partially eliminated as a keto-metabolite in the urine); may alter thyroid function testsAdverse ReactionsThe following adverse drug reactions and incidences are derived from ...
, skin rashes (17.3%), and elevations in hepatic enzymes level (approximately 10% of pts.; varying with enzymes). However, postmarketing data concerning safety of voriconazole are limited. OBJECTIVE: To describe voriconazole adverse drug effects (ADEs) after 4 years of the drug's availability ...