别名 2-Propylpentanoic acid CAS 99-66-1 分子式 C8H16O2 分子量 144.21 储存条件 常温 纯度 Purity≥98% 单位 瓶 生物活性 Valproic acid 是一种 HDAC 抑制剂,IC50 值为 0.5-2 mM,抑制 HDAC1 的活性,(IC50,400 μM),同时可诱导 HDAC2 的降解;Valproic acid抑制VEGF,VEGFR2和bFGF的mRNA和蛋白质表达。
VALPROIC acidORAL cancerPRECANCEROUS conditionsHISTONE acetylationSQUAMOUS cell carcinomaOral squamous cell carcinoma (OSCC) is a frequent human malignancy that demonstrates a range of genetic and epigenetic alterations. Histone deacetylases (HDACs) are key epigenetic regulators of cell-cyc...
基本信息 中文名称:Valproic Acid Impurity 19 英文名称:Valproic Acid Impurity 19 中文同义名: 丙基丙二酸; 2-丙基丙二酸; 丙戊酸钠杂质19; 英文同义名: ALPHA-PROPYLMALONIC ACID; AURORA KA-4358; RARECHEM AM LA 0045; PROPYLMALONIC ACID; 1,1-Butanedicarboxylicacid; 2-Propylmalonic acid; 2-Propylma...
基本信息 中文名称:Valproic Acid Impurity 5 英文名称:Valproic Acid Impurity 5 EINECS:221-696-4 中文同义名: 二烯丙基丙二酸二乙酯; 二烯丙基丙二酸二乙酯,98%; 英文同义名: Diethyl 2,2-diallylmalonate , Tech.; 2,2-(Diallyl)malonic acid diethyl ester; Di-2-propenylpropanedioic acid diethyl es...
. (Qiao.Li@uOttawa.ca) Effects of histone deacetylase inhibitor valproic acid on skeletal myocyte development Qiao Li1,2, Michelle Foote2 & Jihong Chen2 1Department of Cellular and Molecular Medicine, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada, 2Department of Pathology and ...
Microglial abnormality and heterogeneity are also seen in animal models of ASD. Prenatal valproic acid (VPA) exposure changed microglial phenotypes from resting to activated states in the prefrontal cortex and hippocampus regions of infant and adolescent VPA model rats, but microglial activation was alle...
英文名称:Valproic Acid Sodium Salt 纯度:98% CAS编号:1069-66-5 别名:Valproic Acid Sodium Salt 产地:美国进口 分子式:Sodium 2-propylpentanoate; Sodium valproate; 2-Propylpentanoic acid sodium salt 品牌:LKT 包装规格:10 g 上海惠诚生物为广大科研用户提供科学仪器,试剂耗材等专业科研产品服务。
Valproic acid (VA) is a pharmacologically important histone deacetylase inhibitor that recently garnered attention as an anticancer agent. Since the molecular mechanisms behind the multiple effects of VA are unclear, this study was aimed to unravel the c
Our previous study found that the level of CCN1 increases as osteogenic differentiation progresses in tonsil-derived mesenchymal stem cells (TMSCs). This study investigated how CCN1 is regulated through HDAC inhibition in TMSCs and their relationship with osteogenesis. Valproic acid (VPA) (1–5 mM...
Morel C, Christophe A, Maguin-Gaté K, Paoli J, Turner JD, Schroeder H, Grova N. Head-to-Head Study of Developmental Neurotoxicity and Resultant Phenotype in Rats: α-Hexabromocyclododecane versus Valproic Acid, a Recognized Model of Reference for Autism Spectrum Disorders.Toxics. 2022; 10(4...