USP7-MDM2-p53 networkp53 activiationThe ubiquitin-specific protease 7 (USP7)-murine double minute 2 (MDM2)-p53 network plays an important role in the regulation of p53, a tumor suppressor which plays critical roles in regulating cell growth, proliferation, cell cycle progression, apoptosis and ...
【病毒】HAUSP/..与疱疹病毒相关的泛素特异性蛋白酶(HAUSP,也叫USP7)是一种去泛肽化酶——属于泛素特异性加工蛋白酶家族,特别是p53和MDM2在p53–MDM2途径中具有重要的作用。研究人员发现p53和MDM2
Mechanically, FEN1 could inactivate P53 signaling by preventing the ubiquitination and degradation of mouse double minute 2 (MDM2) via recruiting ubiquitin-specific protease 7 (USP7). Interfering USP7 with P22077 significantly reversed the malignant phenotypes activated by FEN1. In conclusion, this ...
1.1 Inhibition of Deubiquitinating Enzyme USP7 Sensitizes CLL Tumor with ATM and p53 Dysfunction by Targeting Both Mdm2/p53 Loop and DNA Repair - Clinical Lymphoma Myeloma and Leukemiadoi:10.1016/j.clml.2011.09.002A. AgathanggelouN. Zlatanou...
C-terminal region of USP7/HAUSP is critical for deubiquitination activity and contains a second mdm2/p53 binding site[J] . Jianhong Ma,John D. Martin,Yu Xue,Leng A. Lor,Karen M. Kennedy-Wilson,Robert H. Sinnamon,Thau F. Ho,Guofeng Zhang,Benjamin Schwartz,Peter J. Tummino,Zhihong Lai....