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41 It is possible that there are additional mechanisms that have not yet been identified, including whether p-MYH9 (Ser1943) could impact the expression of USP22. A more comprehensive and detailed understanding of this topic would require a deeper exploration. By incorporating molecular typing and...
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Download PDF You have full access to this open access article Apoptosis Aims and scope Submit manuscript Yiqiong Song, Longhao Wang, Yuanyuan Zheng, Lanqi Jia, Chunwei Li, Ke Chao, Lifeng Li, Shilong Sun, Yujie Wei, Yahao Ge, Yaqi Yang, Lili Zhu, Yixing Zhang & ...
Download all Document S1. Figures S1–S7 and Tables S4–S8 Table S1. Genes Targeted and shRNAs Used in the Primary and Secondary In Vivo Screens, Related to Figures 1, S1, and S2 Table S2. DUBs Tested in the Primary and Secondary In Vivo Screens, Related to Figures 1, S1, and S2...
Rao, R. Liu, Y. Danna, J. Li, J. Fan, J. Chen, W. Zhang, Q. Zhan A PLK1 kinase inhibitor enhances the chemosensitivity of cisplatin by inducing pyroptosis in oesophageal squamous cell carcinoma EBioMedicine, 41 (2019), pp. 244-255 View PDFView articleView in ScopusGoogle Scholar...
a, Free USP14 wild-type (400 nM) does not cleave multi-chain cyclin B1 conjugates (~110 nM). b, High concentration of free USP14 does not deubiquitinate Ubn–NCB1. USP14 (15 μM) activity on Ubn–NCB1 (~0.45 μM) in the absence of proteasome was tested by incubating ...
41). Although several ubiquitin E3 ligases of stem cell transcription factors (SCTFs) have been identified, little is known about the mechanism and function of the deubiquitinating enzymes that controls the protein levels of these key pluripotency factors in ESC differentiation and function. In this...
FIG. 2D: Inhibitory activity of compound 10 across a panel of 41 purified DUBs using ubiquitin-rhodamine (Ub-Rho) as substrate. FIG. 3A: Characterization of compound 10 binding to USP7 using ribbon diagram of USP7 with compound 10. FIG. 3B: Stereoview of USP7 (light blue) bound to com...