Download all Document S1. Figures S1–S7 and Tables S4–S8 Table S1. Genes Targeted and shRNAs Used in the Primary and Secondary In Vivo Screens, Related to Figures 1, S1, and S2 Table S2. DUBs Tested in the Primary and Secondary In Vivo Screens, Related to Figures 1, S1, and S2...
Supplemental Data 1. Download: Download Acrobat PDF file (66KB) Supplemental Data 2. Download: Download spreadsheet (351KB) Supplemental Data 3. References 1 S. Barker, M. Weinfeld, D. Murray DNA-protein crosslinks: Their induction, repair, and biological consequences Mutat. Res., 589 (2005...
2022;41(1):219. Article CAS PubMed PubMed Central Google Scholar Chen S, Liu Y, Zhou H. Advances in the Development Ubiquitin-Specific Peptidase (USP) Inhibitors. Int J Mol Sci. 2021;22(9):4546. Article CAS PubMed PubMed Central Google Scholar Download references...
41 T-ALL xenografts Female NOD/SCID/IL2Rγ-null (NSG) mice aged six to 8 weeks were kept under pathogen-free conditions according to the Shanghai Medical Experimental Animal Care guidelines. Human JURKAT cells transduced with retroviruses encoding pSIREN-Control shRNA or pSIREN-USP7 shRNA-2 ...
Download PDF Editorial Summary Lung cancer: Targeting a vicious circle Therapies targeting a molecular feedback loop involved in tumor growth may prove valuable for treating non-small-cell lung cancer. Fangbao Ding, Jianbing Huang, and co-workers at Shanghai Jiao Tong University in Shanghai, ...
Oct 17 2024 10:15 BST BUFFALO, N.Y.,Oct. 17, 2024/PRNewswire/ --M&T Bank Corporation("M&T" or "the Company") reports quarterly net income of $721 million or$4.02of diluted earnings per common share. (1) A reconciliation of non-GAAP measures is included in the tables that accompany...
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Nonalcoholic fatty liver disease (NAFLD) occurs due to the accumulation of fat in the liver, leading to fatal liver diseases such as nonalcoholic steatohepatitis (NASH) and cirrhosis. Elucidation of the molecular mechanisms underlying NAFLD is critical f
USP14 is a proteasome-associated de-ubiquitinating enzyme that protects protein substrates from degradation by removing the ubiquitin chain from the proteasome-bound substrate [41]. The post-translational modification process induced by the dysregulation of USP14 is involved in the onset and progression...