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Download PDF You have full access to this open access article Apoptosis Aims and scope Submit manuscript Yiqiong Song, Longhao Wang, Yuanyuan Zheng, Lanqi Jia, Chunwei Li, Ke Chao, Lifeng Li, Shilong Sun, Yujie Wei, Yahao Ge, Yaqi Yang, Lili Zhu, Yixing Zhang & ...
8f, g). USP15 deficiency also led to a considerably lower degree of cell death, as confirmed by the TUNEL assay47, which labels the free 3’-hydroxyl termini of genomic DNA, indicating apoptotic cell death (Fig. 8h). However, tolerance tests for glucose and insulin did not show either...
Similarly, exosomes from CD103+-CSCs promote metastasis in clear-cell renal cell carcinoma by delivering miR-19b-3p [47]. Another study demonstrated that agrin protein derived from extracellular vesicles of pancreatic cancer stem cells promotes YAP activation via LRP-4, aiding non-stem cancer ...
Download: Download Acrobat PDF file (40MB) Document S1. Figures S1–S7 and Tables S4–S8. Download: Download spreadsheet (47KB) Table S1. Genes Targeted and shRNAs Used in the Primary and Secondary In Vivo Screens, Related to Figures 1, S1, and S2. Download: Download spreadsheet (11K...
Download PDF Collection Biology Beyond Boundaries: Mitochondrial and Cell Death in Translational Research Sections Figures References Abstract Introduction Materials and methods Results Discussion Conclusion Data availability References Acknowledgements Funding Author information Ethics declarations Additional ...
HSV-1 USP is expressed independently of VP1/2 as a ∼47 KDa protein, can be detected as early as 12 h post-infection (pi) and is specific for K48 and K63 polyubiquitin chains (Bolstad et al., 2011, Kattenhorn et al., 2005, Kim et al., 2009). USPs are encoded as part of ...
47), ERK2 also negatively regulates the stability of Klf2 (ref. 48). In addition, Nanog is a target of ERK1 and phosphorylation by ERK1 induces Nanog degradation via the E3 ligase FBXW8 (ref. 17). Although it is well established that the LIF–STAT3 pathway is essential for the ...
47 48 49 63 106 108 109 110 111 112 116 and 117 or a pharmaceutically acceptable salt thereof. 19. A pharmaceutical composition comprising a compound of claim 1, or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier. 20. A method of treating a disease or...