The infarct size/area at risk (IS/AAR) ratio of USP5-deficient mice was smaller following 45 min of ischemia and 6 h of reperfusion compared to WT mice (Fig. 6B, P < 0.05). Moreover, the AAR as a percentage of the left ventricle (AAR/LV) in USP5-deficient mice was ...
Download: Download spreadsheet (119KB) Table S3. Results from In Vivo RNAi Screens, Related to Figures 1, S1, and S2. Download: Download Acrobat PDF file (45MB) Document S2. Article plus Supplemental Information. References Adorno et al., 2013 M. Adorno, S. Sikandar, S.S. Mitra, A....
USP11 confers cellular resistance to PARP1 inhibitors that trap PARP1 to DNA (45). However, the function of USP11 in DPC repair is not reported. In this study, we show that USP11 is a novel interactor of SPRTN and deubiquitinates SPRTN in cells and in vitro. Depletion of USP11 leads...
Interferon (IFN)-γ-mediated immune response plays an important role in tumor immunosurveillance. However, the regulation of IFN-γ-mediated tumorigenesis and immune response remains elusive. USP18, an interferon stimulating response element, regulates I
USP <63> Mycoplasma Tests: A New Regulation for Mycoplasma Testing Published on: August 1, 2010 Raymond W. Nims, PhD BioPharm International, BioPharm International-08-01-2010, Volume 23, Issue 8 Pages: 40–45 What you need to know about USP chapter <63>. ABSTRACT The United States Pharmac...
Download PDF Editorial Summary Lung cancer: Targeting a vicious circle Therapies targeting a molecular feedback loop involved in tumor growth may prove valuable for treating non-small-cell lung cancer. Fangbao Ding, Jianbing Huang, and co-workers at Shanghai Jiao Tong University in Shanghai, ...
(pNET) and one cohort with advanced extra-pancreatic NET (epNET). These data are being presented today at the 2024European Society for Medical Oncology Congress(ESMO 2024) during the Proffered Paper Session: NETs and Endocrine Tumours at2:45 p.m. CETand were simultaneously published in theN...
Interestingly, USP7 inhibition caused degradation of ICN1 in T-ALL cell lines regardless of the status of NOTCH1 (JURKAT and CCRF-CEM cells have FBW7 mutations; MOLT-4 and KOPT-K1 cells have PEST domain mutations;45 CUTLL1 cells harbor a chromosomal translocation at (7;9)(q34;q34)46)...
Oct 17 2024 10:15 BST BUFFALO, N.Y.,Oct. 17, 2024/PRNewswire/ --M&T Bank Corporation("M&T" or "the Company") reports quarterly net income of $721 million or$4.02of diluted earnings per common share. (1) A reconciliation of non-GAAP measures is included in the tables that accompany...