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Download PDF You have full access to this open access article From View current issue Xiangling Xiao, Jie Shi, Chuan He, Xia Bu, Yishuang Sun, Minling Gao, Bolin Xiang, Wenjun Xiong, Panpan Dai, Qi Mao, Xixin Xing, Yingmeng Yao, Haisheng Yu, Gaoshan Xu, Siqi...
cell lines. Using whole-cell current recordings and surface biotinylation assays, we show that USP2-45 specifically decreases both the amplitude of Cavcurrents and the amount of Cav1.2 subunits inserted at the plasma membrane. Importantly, co-expression of the α2δ-1 accessory subunit is necessar...
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The infarct size/area at risk (IS/AAR) ratio of USP5-deficient mice was smaller following 45 min of ischemia and 6 h of reperfusion compared to WT mice (Fig. 6B, P < 0.05). Moreover, the AAR as a percentage of the left ventricle (AAR/LV) in USP5-deficient mice was ...
Interferon (IFN)-γ-mediated immune response plays an important role in tumor immunosurveillance. However, the regulation of IFN-γ-mediated tumorigenesis and immune response remains elusive. USP18, an interferon stimulating response element, regulates I
Download: Download spreadsheet (119KB) Table S3. Results from In Vivo RNAi Screens, Related to Figures 1, S1, and S2. Download: Download Acrobat PDF file (45MB) Document S2. Article plus Supplemental Information. References Adorno et al., 2013 M. Adorno, S. Sikandar, S.S. Mitra, A....
a, Free USP14 wild-type (400 nM) does not cleave multi-chain cyclin B1 conjugates (~110 nM). b, High concentration of free USP14 does not deubiquitinate Ubn–NCB1. USP14 (15 μM) activity on Ubn–NCB1 (~0.45 μM) in the absence of proteasome was tested by incubating ...
USP21 regulates centrosome- and microtubule-associated functions18,45. Moreover, USP21 affects the transcription of NF-κB p65 through deubiquitinating and stabilizing interleukin-33 in the nucleus46. In this study, we provided evidence showing that USP21 specifically deubiquitinated and stabilized ...