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Download PDF You have full access to this open access article Signal Transduction and Targeted Therapy Qiaonan Shan, Lu Yin, Qifan Zhan, Jiongjie Yu, Sheng Pan, Jianyong Zhuo, Wei Zhou, Jiaqi Bao, Lincheng Zhang, Jiachen Hong, Jianan Xiang, Qingyang Que, Kangchen Chen, ...
Download PDF You have full access to this open access article Apoptosis Aims and scope Submit manuscript Yiqiong Song, Longhao Wang, Yuanyuan Zheng, Lanqi Jia, Chunwei Li, Ke Chao, Lifeng Li, Shilong Sun, Yujie Wei, Yahao Ge, Yaqi Yang, Lili Zhu, Yixing Zhang & ...
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Adenovirus vector is the efficient system to deliver target DNA therapy in vivo[39], as it has higher infection efficiency on both tumor cells and immune cells. In our study, delivering USP18 into solid tumor could be accomplished by intra-tumor injection of adenovirus containing USP18 cDNA. ...
13k Accesses 39 Altmetric Metrics details Abstract USP14 is a major regulator of the proteasome and one of three proteasome-associated deubiquitinating enzymes1,2,3,4,5,6,7,8,9. Its effects on protein turnover are substrate-specific, for unknown reasons. We report that USP14 shows a marked...
Nanog is a master pluripotency factor of embryonic stem cells (ESCs). Stable expression of Nanog is essential to maintain the stemness of ESCs. However, Nanog is a short-lived protein and quickly degraded by the ubiquitin-dependent proteasome system. Her
Download: Download high-res image (184KB) Download: Download full-size image FIGURE 3. USP19 stabilizes HIF-1α independent of catalytic activity. A, active site labeling with the HA-ubiquitin-VME probe in lysates from cells expressing Myc-USP19 and the mutant Myc-USP19(C506S). The upper...
Download: Download high-res image (156KB) Download: Download full-size image Figure 1. BCL9 is physically associated with USP9X. A, immunoaffinity purification and MS analysis of BCL9-containing protein complexes. HeLa cells with Dox-inducible expression of stably integrated FLAG–BCL9 were collec...